%0 Journal Article
%A Keipert, Lisa M
%A Wurster, Claudia
%A Uzelac, Zeljko
%A Dorst, Johannes
%A Schuster, Joachim
%A Wollinsky, Kurt
%A Ludolph, Albert
%A Lule, Dorothee
%T Pain in adult and adolescent patients with 5q-associated Spinal Muscular Atrophy - an often underrated phenomenon.
%J Journal of neuromuscular diseases
%V 12
%N 5
%@ 2214-3599
%C Amsterdam
%I IOS Press
%M DZNE-2025-00978
%P 662 - 669
%D 2025
%X Spinal muscular atrophy (SMA) is a genetic disorder leading to progressive muscle weakness and atrophy. Pain in SMA may be the consequence of the underlying neuromuscular disease but has hardly been investigated so far.To assess pain in SMA and its interaction with patient's wellbeing.In a prospective, cross-sectional study design, 70 adult and adolescent SMA patients (median age 30 years, IQR 21-49 years, types I-IV) were assessed at the Department of Neurology, Ulm University hospital. Pain was evaluated with a self-adapted Pain Scale, depressiveness with the ALS-Depression-Inventory-12-Items (ADI-12) and global Quality of Life (gQoL) with the Anamnestic Comparative Self-Assessment (ACSA).We found an intermittent frequency of pain in 80
%K Humans
%K Male
%K Adult
%K Female
%K Cross-Sectional Studies
%K Muscular Atrophy, Spinal: complications
%K Muscular Atrophy, Spinal: genetics
%K Muscular Atrophy, Spinal: psychology
%K Adolescent
%K Middle Aged
%K Young Adult
%K Quality of Life
%K Prospective Studies
%K Pain: etiology
%K Pain: epidemiology
%K Pain Measurement
%K Depression
%K SMA (Other)
%K depression (Other)
%K depressiveness (Other)
%K pain (Other)
%K quality of life (Other)
%K spinal muscular atrophy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40396429
%R 10.1177/22143602251325773
%U https://pub.dzne.de/record/280894