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000280912 0247_ $$2doi$$a10.1002/mdc3.70061
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000280912 041__ $$aEnglish
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000280912 1001_ $$aAndersson, Hampus$$b0
000280912 245__ $$aSimultaneous Nonmotor Symptoms Do Not Affect General Validity but Interpretation of the Parkinson's Disease Motor Diary.
000280912 260__ $$aNew York, NY$$bWiley$$c2025
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000280912 520__ $$aMotor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited.This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion).A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS.Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states.Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.
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000280912 650_7 $$2Other$$aPD home motor diary
000280912 650_7 $$2Other$$aParkinson's disease
000280912 650_7 $$2Other$$amotor fluctuations
000280912 650_7 $$2Other$$anonmotor symptoms
000280912 650_7 $$2Other$$avalidity
000280912 650_2 $$2MeSH$$aHumans
000280912 650_2 $$2MeSH$$aParkinson Disease: physiopathology
000280912 650_2 $$2MeSH$$aParkinson Disease: complications
000280912 650_2 $$2MeSH$$aParkinson Disease: diagnosis
000280912 650_2 $$2MeSH$$aMale
000280912 650_2 $$2MeSH$$aFemale
000280912 650_2 $$2MeSH$$aAged
000280912 650_2 $$2MeSH$$aMiddle Aged
000280912 650_2 $$2MeSH$$aReproducibility of Results
000280912 650_2 $$2MeSH$$aProspective Studies
000280912 650_2 $$2MeSH$$aSeverity of Illness Index
000280912 650_2 $$2MeSH$$aCohort Studies
000280912 7001_ $$aBremer, Alexander$$b1
000280912 7001_ $$00000-0003-2874-9817$$aGandor, Florin$$b2
000280912 7001_ $$aEbersbach, Georg$$b3
000280912 7001_ $$0P:(DE-2719)2813524$$aLöhle, Matthias$$b4$$udzne
000280912 7001_ $$aOdin, Per$$b5
000280912 7001_ $$0P:(DE-2719)9000306$$aStorch, Alexander$$b6$$eLast author
000280912 773__ $$0PERI:(DE-600)2772809-2$$a10.1002/mdc3.70061$$gVol. 12, no. 7, p. 979 - 984$$n7$$p979 - 984$$tMovement disorders clinical practice$$v12$$x2330-1619$$y2025
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