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@ARTICLE{Andersson:280912,
      author       = {Andersson, Hampus and Bremer, Alexander and Gandor, Florin
                      and Ebersbach, Georg and Löhle, Matthias and Odin, Per and
                      Storch, Alexander},
      title        = {{S}imultaneous {N}onmotor {S}ymptoms {D}o {N}ot {A}ffect
                      {G}eneral {V}alidity but {I}nterpretation of the
                      {P}arkinson's {D}isease {M}otor {D}iary.},
      journal      = {Movement disorders clinical practice},
      volume       = {12},
      number       = {7},
      issn         = {2330-1619},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-00995},
      pages        = {979 - 984},
      year         = {2025},
      abstract     = {Motor fluctuations are routinely documented using the
                      Parkinson's disease (PD) home diary. However, the validity
                      of this diary when compared to clinical observers is
                      limited.This study disassembled the effects of nonmotor
                      symptoms (NMS) on inter-method agreement between the PD home
                      motor diary and clinical observers (outside validity
                      criterion).A prospective observational VALIDATE-PD cohort
                      study in advanced PD assessing symptom severity by
                      simultaneous hourly ratings using the home diary (Off, On,
                      dyskinetic state) and a nonmotor diary (11 key NMSs) was
                      performed. Test validity measures (accuracy and Cohen's κ)
                      were compared between hours with and without co-occurring
                      NMS.Four hundred eighty-seven hourly time periods from 47
                      participants were analyzed. Inter-method agreement
                      (accuracy, Cohen's κ) of the motor diary was independent of
                      co-occurring NMSs, but simultaneous NMSs inversely influence
                      false ratings of motor Off and On states.Simultaneously
                      occurring NMSs do not affect general validity but the
                      interpretation of the PD home motor diary.},
      keywords     = {Humans / Parkinson Disease: physiopathology / Parkinson
                      Disease: complications / Parkinson Disease: diagnosis / Male
                      / Female / Aged / Middle Aged / Reproducibility of Results /
                      Prospective Studies / Severity of Illness Index / Cohort
                      Studies / PD home motor diary (Other) / Parkinson's disease
                      (Other) / motor fluctuations (Other) / nonmotor symptoms
                      (Other) / validity (Other)},
      cin          = {AG Storch},
      ddc          = {610},
      cid          = {I:(DE-2719)5000014},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40178037},
      pmc          = {pmc:PMC12275004},
      doi          = {10.1002/mdc3.70061},
      url          = {https://pub.dzne.de/record/280912},
}