%0 Conference Paper
%A Wachinger, Christian
%A Rieckmann, Anna
%A Reuter, Martin
%Y Descoteaux, Maxime
%Y Maier-Hein, Lena
%Y Franz, Alfred
%Y Jannin, Pierre
%Y Collins, D. Louis
%Y Duchesne, Simon
%T Latent Processes Governing Neuroanatomical Change in Aging and Dementia
%V 10435
%C Cham
%I Springer International Publishing
%M DZNE-2025-01008
%@ 978-3-319-66178-0 (print)
%B Lecture Notes in Computer Science
%P 30 - 37
%D 2017
%< Medical Image Computing and Computer Assisted Intervention − MICCAI 2017 / Descoteaux, Maxime (Editor) [https://orcid.org/0000-0002-8191-2129] ; Cham : Springer International Publishing, 2017, Chapter 4 ; ISSN: 0302-9743=1611-3349 ; ISBN: 978-3-319-66178-0=978-3-319-66179-7 ; doi:10.1007/978-3-319-66179-7
%X Clinically normal aging and pathological processes cause structural changes in the brain. These changes likely occur in overlapping regions that accommodate neural systems with high susceptibility to deleterious factors. Due to the overlap, the separation between aging and pathological processes is challenging when analyzing brain structures independently. We propose to identify multivariate latent processes that govern cross-sectional and longitudinal neuroanatomical changes across the brain in aging and dementia. A discriminative representation of neuroanatomy is obtained from spectral shape descriptors in the BrainPrint. We identify latent factors by maximizing the covariance between morphological change and response variables of age and a proxy for dementia. Our results reveal cross-sectional and longitudinal patterns of change in neuroanatomy that distinguishes aging processes from disease processes. Finally, latent processes do not only yield a parsimonious model but also a significantly improved prediction accuracy.
%B Medical Image Computing and Computer Assisted Intervention
%C 11 Sep 2017 - 13 Sep 2017, Quebec City (Canada)
Y2 11 Sep 2017 - 13 Sep 2017
M2 Quebec City, Canada
%F PUB:(DE-HGF)8 ; PUB:(DE-HGF)7
%9 Contribution to a conference proceedingsContribution to a book
%R 10.1007/978-3-319-66179-7_4
%U https://pub.dzne.de/record/280925