TY  - CONF
AU  - Wachinger, Christian
AU  - Rieckmann, Anna
AU  - Reuter, Martin
A3  - Descoteaux, Maxime
A3  - Maier-Hein, Lena
A3  - Franz, Alfred
A3  - Jannin, Pierre
A3  - Collins, D. Louis
A3  - Duchesne, Simon
TI  - Latent Processes Governing Neuroanatomical Change in Aging and Dementia
VL  - 10435
CY  - Cham
PB  - Springer International Publishing
M1  - DZNE-2025-01008
SN  - 978-3-319-66178-0 (print)
T2  - Lecture Notes in Computer Science
SP  - 30 - 37
PY  - 2017
AB  - Clinically normal aging and pathological processes cause structural changes in the brain. These changes likely occur in overlapping regions that accommodate neural systems with high susceptibility to deleterious factors. Due to the overlap, the separation between aging and pathological processes is challenging when analyzing brain structures independently. We propose to identify multivariate latent processes that govern cross-sectional and longitudinal neuroanatomical changes across the brain in aging and dementia. A discriminative representation of neuroanatomy is obtained from spectral shape descriptors in the BrainPrint. We identify latent factors by maximizing the covariance between morphological change and response variables of age and a proxy for dementia. Our results reveal cross-sectional and longitudinal patterns of change in neuroanatomy that distinguishes aging processes from disease processes. Finally, latent processes do not only yield a parsimonious model but also a significantly improved prediction accuracy.
T2  - Medical Image Computing and Computer Assisted Intervention
CY  - 11 Sep 2017 - 13 Sep 2017, Quebec City (Canada)
Y2  - 11 Sep 2017 - 13 Sep 2017
M2  - Quebec City, Canada
LB  - PUB:(DE-HGF)8 ; PUB:(DE-HGF)7
DO  - DOI:10.1007/978-3-319-66179-7_4
UR  - https://pub.dzne.de/record/280925
ER  -