000280929 001__ 280929
000280929 005__ 20260107150620.0
000280929 0247_ $$2doi$$a10.1007/978-3-319-98605-0_4
000280929 037__ $$aDZNE-2025-01012
000280929 1001_ $$aHashkes, Philip J.$$b0$$eEditor
000280929 245__ $$aPattern Recognition Receptors in Autoinflammation
000280929 260__ $$aCham$$bSpringer International Publishing$$c2019
000280929 29510 $$aTextbook of Autoinflammation / Hashkes, Philip J. (Editor) ; Cham : Springer International Publishing, 2019, Chapter 4 ; ISBN: 978-3-319-98604-3 ; doi:10.1007/978-3-319-98605-0
000280929 300__ $$a61 - 87
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000280929 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$bcontb$$mcontb$$s1758102525_31852
000280929 520__ $$aThe immune system is essential for maintenance of tissue homeostasis. This task requires that immune cells detect and respond to dyshomeostatic states (when homeostasis has broken down) that can occur during invasion of the host with pathogenic microbes, after sterile trauma of tissues or during metabolic derangements. Research in the field of innate immunity has uncovered many molecular mechanisms by which the immune system can prevent the spread of infection, restore damaged tissues and respond to altered metabolism. These pathways involve different classes of pattern recognition receptors, some of which can directly detect minimal motifs (patterns) that are common to multiple pathogens or types of damaged cells. Here, we summarize the general concepts that have been developed to explain how immune recognition of dyshomeostasis is achieved and discuss our current knowledge of the innate immune signaling receptors that are known to directly bind ligands.
000280929 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
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000280929 7001_ $$aLaxer, Ronald M.$$b1$$eEditor
000280929 7001_ $$aSimon, Anna$$b2$$eEditor
000280929 7001_ $$aSaavedra, Victor$$b3
000280929 7001_ $$aMoghaddas, Fiona$$b4
000280929 7001_ $$0P:(DE-2719)2000062$$aLatz, Eicke$$b5$$udzne
000280929 7001_ $$aMasters, Seth L.$$b6
000280929 773__ $$a10.1007/978-3-319-98605-0_4
000280929 909CO $$ooai:pub.dzne.de:280929$$pVDB
000280929 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000062$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000280929 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000280929 9141_ $$y2019
000280929 9201_ $$0I:(DE-2719)1013024$$kAG Latz$$lInnate Immunity in Neurodegeneration$$x0
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000280929 980__ $$aVDB
000280929 980__ $$aI:(DE-2719)1013024
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