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000280933 1001_ $$aPan-Montojo, F.$$b0
000280933 245__ $$aThe role of environmental toxins and inflammation in Parkinson's disease pathophysiology: a historical perspective and research-based evidence
000280933 260__ $$bElsevier$$c2020
000280933 29510 $$aDiagnosis and Management in Parkinson's Disease / Pan-Montojo, F. ; : Elsevier, 2020, ; ISBN: 9780128159460 ; doi:10.1016/B978-0-12-815946-0.00003-X
000280933 300__ $$a29 - 55
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000280933 520__ $$aParkinson's disease (PD) was first described by the English physician James Parkinson in his work An Essay on the Shaking Palsy in 1817. This correlates well with the beginning of the industrial and chemical revolution in Europe during the late 18th and 19th centuries. This period and the time afterward are linked to the increased production and use of chemicals and pesticides. In this chapter, we review (1) the epidemiological evidence linking the appearance of PD to an increase in exposure to environmental toxins, and (2) the possible mechanisms underlying this correlation obtained from in vitro and in vivo experimental studies.
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000280933 7001_ $$0P:(DE-2719)2812785$$aLöwenbrück, Kai$$b1$$udzne
000280933 7001_ $$aReichmann, H.$$b2
000280933 773__ $$a10.1016/B978-0-12-815946-0.00003-X
000280933 8564_ $$uhttps://pub.dzne.de/record/280933/files/DZNE-2025-01016.pdf
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000280933 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812785$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
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000280933 9201_ $$0I:(DE-2719)1710012$$kAG Falkenburger$$lTranslational Parkinson Research$$x0
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