TY  - CHAP
AU  - Pan-Montojo, F.
AU  - Löwenbrück, Kai
AU  - Reichmann, H.
TI  - The role of environmental toxins and inflammation in Parkinson's disease pathophysiology: a historical perspective and research-based evidence
PB  - Elsevier
M1  - DZNE-2025-01016
SP  - 29 - 55
PY  - 2020
AB  - Parkinson's disease (PD) was first described by the English physician James Parkinson in his work An Essay on the Shaking Palsy in 1817. This correlates well with the beginning of the industrial and chemical revolution in Europe during the late 18th and 19th centuries. This period and the time afterward are linked to the increased production and use of chemicals and pesticides. In this chapter, we review (1) the epidemiological evidence linking the appearance of PD to an increase in exposure to environmental toxins, and (2) the possible mechanisms underlying this correlation obtained from in vitro and in vivo experimental studies.
LB  - PUB:(DE-HGF)7
DO  - DOI:10.1016/B978-0-12-815946-0.00003-X
UR  - https://pub.dzne.de/record/280933
ER  -