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@ARTICLE{Herzog:280942,
      author       = {Herzog, Maximilian Jonathan and Müller, Patrick and
                      Lechner, Katharina and Stiebler, Marvin and Arndt, Philipp
                      and Kunz, Matthias and Ahrens, Dörte and Schmeißer,
                      Alexander and Schreiber, Stefanie and Braun-Dullaeus,
                      Ruediger C},
      title        = {{A}rterial stiffness and vascular aging: mechanisms,
                      prevention, and therapy.},
      journal      = {Signal transduction and targeted therapy},
      volume       = {10},
      number       = {1},
      issn         = {2095-9907},
      address      = {London},
      publisher    = {Macmillan Publishers, part of Springer Nature},
      reportid     = {DZNE-2025-01025},
      pages        = {282},
      year         = {2025},
      abstract     = {Cardiovascular diseases are the leading cause of morbidity
                      and mortality worldwide. The central underlying mechanisms
                      of cardiovascular diseases are vascular aging and associated
                      arterial stiffness. Arterial stiffness is characterized by
                      structural (e.g., tunica media calcification, alterations in
                      vascular smooth muscle cells, and fibrosis) and functional
                      (e.g., loss of Windkessel function, elevated pulse pressure,
                      and development of isolated systolic hypertension) vascular
                      changes that cause microvascular dysfunction and end-organ
                      damage (e.g., heart failure, vascular dementia, hypertensive
                      retinopathy, and chronic kidney disease). Current research
                      indicates that arterial stiffness is an independent risk
                      factor for cardiovascular diseases and represents a
                      potential target for personalized prevention and therapeutic
                      approaches. In this review, we summarize the
                      pathophysiological mechanisms of vascular aging and arterial
                      stiffness, outline the resulting end-organ damage, present
                      different methods for the measurement of arterial stiffness,
                      highlight the potential role of prevention and therapy, and
                      provide future perspectives for arterial stiffness research.
                      The purpose of this review is to provide a state-of-the-art
                      interdisciplinary and translational approach to arterial
                      stiffness, highlighting unique pathophysiological mechanisms
                      (e.g., perivascular adipose tissue, extracellular vesicles),
                      clinical relevance, and future directions.},
      subtyp        = {Review Article},
      keywords     = {Humans / Vascular Stiffness: genetics / Aging: pathology /
                      Cardiovascular Diseases: physiopathology / Cardiovascular
                      Diseases: therapy / Cardiovascular Diseases: prevention $\&$
                      control / Cardiovascular Diseases: pathology / Muscle,
                      Smooth, Vascular: pathology / Muscle, Smooth, Vascular:
                      metabolism / Muscle, Smooth, Vascular: physiopathology /
                      Animals},
      cin          = {AG Müller / AG Schreiber},
      ddc          = {610},
      cid          = {I:(DE-2719)1310003 / I:(DE-2719)1310010},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40887468},
      doi          = {10.1038/s41392-025-02346-0},
      url          = {https://pub.dzne.de/record/280942},
}