Home > Publications Database > PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation. > print

001     280948
005     20250921001957.0
024 7 _ |a 10.1016/j.celrep.2025.115735
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024 7 _ |a pmid:40402745
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024 7 _ |a 2211-1247
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024 7 _ |a 2639-1856
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024 7 _ |a altmetric:177409675
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037 _ _ |a DZNE-2025-01030
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Madej, Magdalena
|b 0
245 _ _ |a PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation.
260 _ _ |a Maryland Heights, MO
|c 2025
|b Cell Press
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Pseudouridine synthases (PUSs) catalyze the isomerization of uridine (U)-to-pseudouridine (Ψ) and have emerging roles in development and disease. How PUSs adapt gene expression under stress remains mostly unexplored. We identify an unconventional role for the Ψ 'writer' PUS10 impacting intracellular innate immunity. Using Pus10 knockout mice, we uncover cell-intrinsic upregulation of interferon (IFN) signaling, conferring resistance to inflammation in vivo. Pus10 loss alters tRNA-derived small RNAs (tdRs) abundance, perturbing translation and endogenous retroelements expression. These alterations promote proinflammatory RNA-DNA hybrids accumulation, potentially activating cyclic GMP-AMP synthase (cGAS)-stimulator of interferon gene (STING). Supplementation with selected tdR pools partly rescues these effects through interactions with RNA processing factors that modulate immune responses, revealing a regulatory circuit that counteracts cell-intrinsic inflammation. By extension, we define a PUS10-specific molecular fingerprint linking its dysregulation to human autoimmune disorders, including inflammatory bowel diseases. Collectively, these findings establish PUS10 as a viral mimicry modulator, with broad implications for innate immune homeostasis and autoimmunity.
536 _ _ |a 352 - Disease Mechanisms (POF4-352)
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|c POF4-352
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|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a CP: Molecular biology
|2 Other
650 _ 7 |a PUS10
|2 Other
650 _ 7 |a RNA-DNA hybrids
|2 Other
650 _ 7 |a cGAS-STING
|2 Other
650 _ 7 |a hematopoietic stem cell
|2 Other
650 _ 7 |a inflammation
|2 Other
650 _ 7 |a inflammatory bowel disease
|2 Other
650 _ 7 |a interferon
|2 Other
650 _ 7 |a pseudouridine
|2 Other
650 _ 7 |a tRNA-derived small RNAs
|2 Other
650 _ 7 |a transposable elements
|2 Other
650 _ 7 |a viral mimicry
|2 Other
650 _ 7 |a Retroelements
|2 NLM Chemicals
650 _ 7 |a RNA, Transfer
|0 9014-25-9
|2 NLM Chemicals
650 _ 7 |a pseudouridine synthases
|0 EC 5.4.99.-
|2 NLM Chemicals
650 _ 7 |a Intramolecular Transferases
|0 EC 5.4.-
|2 NLM Chemicals
650 _ 7 |a Hydro-Lyases
|0 EC 4.2.1.-
|2 NLM Chemicals
650 _ 7 |a Interferons
|0 9008-11-1
|2 NLM Chemicals
650 _ 7 |a Membrane Proteins
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Retroelements: genetics
|2 MeSH
650 _ 2 |a Inflammation: genetics
|2 MeSH
650 _ 2 |a Inflammation: pathology
|2 MeSH
650 _ 2 |a Inflammation: metabolism
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a RNA, Transfer: metabolism
|2 MeSH
650 _ 2 |a RNA, Transfer: genetics
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Immunity, Innate
|2 MeSH
650 _ 2 |a Intramolecular Transferases: metabolism
|2 MeSH
650 _ 2 |a Intramolecular Transferases: genetics
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Hydro-Lyases: metabolism
|2 MeSH
650 _ 2 |a Hydro-Lyases: genetics
|2 MeSH
650 _ 2 |a Interferons: metabolism
|2 MeSH
650 _ 2 |a Signal Transduction
|2 MeSH
650 _ 2 |a Membrane Proteins: metabolism
|2 MeSH
700 1 _ |a Ngoc, Phuong Cao Thi
|b 1
700 1 _ |a Muthukumar, Sowndarya
|b 2
700 1 _ |a Konturek-Cieśla, Anna
|b 3
700 1 _ |a Tucciarone, Silvia
|b 4
700 1 _ |a Germanos, Alexandre
|b 5
700 1 _ |a Ashworth, Christian
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700 1 _ |a Kotarsky, Knut
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700 1 _ |a Ghosh, Sudip
|b 8
700 1 _ |a Fan, Zhimeng
|b 9
700 1 _ |a Fritz, Helena
|b 10
700 1 _ |a Pascual-Gonzalez, Izei
|b 11
700 1 _ |a Huerta, Alain
|b 12
700 1 _ |a Guzzi, Nicola
|b 13
700 1 _ |a Colazzo, Anita
|b 14
700 1 _ |a Beneventi, Giulia
|b 15
700 1 _ |a Lee, Hang-mao
|0 P:(DE-2719)2814197
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700 1 _ |a Cieśla, Maciej
|b 17
700 1 _ |a Douse, Christopher
|b 18
700 1 _ |a Kato, Hiroki
|b 19
700 1 _ |a Swaminathan, Vinay
|b 20
700 1 _ |a Agace, William W
|b 21
700 1 _ |a Castellanos-Rubio, Ainara
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700 1 _ |a Salomoni, Paolo
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700 1 _ |a Bryder, David
|b 24
700 1 _ |a Bellodi, Cristian
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773 _ _ |a 10.1016/j.celrep.2025.115735
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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