%0 Journal Article
%A Bewernick, Bettina
%A Buschmann, Julijana
%A Heser, Kathrin
%A Kleineidam, Luca
%A Domschke, Katharina
%A Elsaesser, Moritz
%A Zehender, Nadine
%A Luppa, Melanie
%A Hellmich, Martin
%A Peters, Oliver
%A Froelich, Lutz
%A Riedel-Heller, Steffi
%A Schramm, Elisabeth
%A Hautzinger, Martin
%A Jessen, Frank
%A Dafsari, Forugh S
%A Wagner, Michael
%T The effect of cognition and age on the efficacy of psychotherapy in late-life depression.
%J Journal of affective disorders
%V 391
%@ 0165-0327
%C Amsterdam [u.a.]
%I Elsevier Science
%M DZNE-2025-01036
%P 119881
%D 2025
%X Cognitive impairment is prevalent in older age and in patients with depression, which may limit the efficacy of psychotherapy for late-life depression (LLD). We analyzed the effect of age and baseline cognition on the efficacy of psychotherapy in LLD.This secondary analysis of a randomized controlled multicenter study included 213 participants (60-92 years) with moderate to severe depression who had received either supportive psychotherapy (SUI) or an LLD-specific cognitive behavioral therapy (LLD-CBT), both of which led to a substantial reduction in depressive symptoms. We examined the influence of age and baseline cognition, assessed with the CERAD-plus neuropsychological battery, on changes in the Geriatric Depression Scale (GDS) at the end of treatment and at 6-month follow-up. Trial registration at ClinicalTrials.gov (NCT03735576) and DRKS (DRKS00013769).Baseline cognition was slightly below norms (<1SD), with 15 
%K Age (Other)
%K Cognition (Other)
%K Late-life depression (Other)
%K Predictors of treatment efficacy (Other)
%K Psychotherapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40669702
%R 10.1016/j.jad.2025.119881
%U https://pub.dzne.de/record/280954