TY  - JOUR
AU  - Bewernick, Bettina
AU  - Buschmann, Julijana
AU  - Heser, Kathrin
AU  - Kleineidam, Luca
AU  - Domschke, Katharina
AU  - Elsaesser, Moritz
AU  - Zehender, Nadine
AU  - Luppa, Melanie
AU  - Hellmich, Martin
AU  - Peters, Oliver
AU  - Froelich, Lutz
AU  - Riedel-Heller, Steffi
AU  - Schramm, Elisabeth
AU  - Hautzinger, Martin
AU  - Jessen, Frank
AU  - Dafsari, Forugh S
AU  - Wagner, Michael
TI  - The effect of cognition and age on the efficacy of psychotherapy in late-life depression.
JO  - Journal of affective disorders
VL  - 391
SN  - 0165-0327
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2025-01036
SP  - 119881
PY  - 2025
AB  - Cognitive impairment is prevalent in older age and in patients with depression, which may limit the efficacy of psychotherapy for late-life depression (LLD). We analyzed the effect of age and baseline cognition on the efficacy of psychotherapy in LLD.This secondary analysis of a randomized controlled multicenter study included 213 participants (60-92 years) with moderate to severe depression who had received either supportive psychotherapy (SUI) or an LLD-specific cognitive behavioral therapy (LLD-CBT), both of which led to a substantial reduction in depressive symptoms. We examined the influence of age and baseline cognition, assessed with the CERAD-plus neuropsychological battery, on changes in the Geriatric Depression Scale (GDS) at the end of treatment and at 6-month follow-up. Trial registration at ClinicalTrials.gov (NCT03735576) and DRKS (DRKS00013769).Baseline cognition was slightly below norms (<1SD), with 15 
KW  - Age (Other)
KW  - Cognition (Other)
KW  - Late-life depression (Other)
KW  - Predictors of treatment efficacy (Other)
KW  - Psychotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40669702
DO  - DOI:10.1016/j.jad.2025.119881
UR  - https://pub.dzne.de/record/280954
ER  -