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@ARTICLE{Bewernick:280954,
      author       = {Bewernick, Bettina and Buschmann, Julijana and Heser,
                      Kathrin and Kleineidam, Luca and Domschke, Katharina and
                      Elsaesser, Moritz and Zehender, Nadine and Luppa, Melanie
                      and Hellmich, Martin and Peters, Oliver and Froelich, Lutz
                      and Riedel-Heller, Steffi and Schramm, Elisabeth and
                      Hautzinger, Martin and Jessen, Frank and Dafsari, Forugh S
                      and Wagner, Michael},
      title        = {{T}he effect of cognition and age on the efficacy of
                      psychotherapy in late-life depression.},
      journal      = {Journal of affective disorders},
      volume       = {391},
      issn         = {0165-0327},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2025-01036},
      pages        = {119881},
      year         = {2025},
      abstract     = {Cognitive impairment is prevalent in older age and in
                      patients with depression, which may limit the efficacy of
                      psychotherapy for late-life depression (LLD). We analyzed
                      the effect of age and baseline cognition on the efficacy of
                      psychotherapy in LLD.This secondary analysis of a randomized
                      controlled multicenter study included 213 participants
                      (60-92 years) with moderate to severe depression who had
                      received either supportive psychotherapy (SUI) or an
                      LLD-specific cognitive behavioral therapy (LLD-CBT), both of
                      which led to a substantial reduction in depressive symptoms.
                      We examined the influence of age and baseline cognition,
                      assessed with the CERAD-plus neuropsychological battery, on
                      changes in the Geriatric Depression Scale (GDS) at the end
                      of treatment and at 6-month follow-up. Trial registration at
                      ClinicalTrials.gov (NCT03735576) and DRKS
                      (DRKS00013769).Baseline cognition was slightly below norms
                      (<1SD), with 15 $\%$ of patients meeting criteria for Mild
                      Cognitive Impairment (MCI). GDS change at the end of
                      treatment was not significantly associated with baseline
                      cognition or MCI status, although additional interaction
                      analyses suggest that, in the SUI group, lower baseline
                      cognitive performance was associated with reduced treatment
                      efficacy at follow-up only. Additionally, we found that
                      higher age predicted a smaller reduction in GDS scores both
                      at end-of-treatment and at follow-up in both treatment
                      groups.Higher age, but not lower cognitive performance, was
                      associated with reduced psychotherapy efficacy. Thus,
                      age-related factors should be considered in psychotherapy.},
      keywords     = {Age (Other) / Cognition (Other) / Late-life depression
                      (Other) / Predictors of treatment efficacy (Other) /
                      Psychotherapy (Other)},
      cin          = {AG Wagner / AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)1011201 / I:(DE-2719)1011102},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40669702},
      doi          = {10.1016/j.jad.2025.119881},
      url          = {https://pub.dzne.de/record/280954},
}