%0 Journal Article
%A Kreye, Jakob
%A Morgenlander, William R
%A Thakar, Manjusha
%A Schulte-Frankenfeld, Poul M
%A Schott, Sarah
%A Bünger, Isabel
%A Kornau, Hans-Christian
%A Angkeow, Julia W
%A Jayaraman, Sahana
%A Otto, Carolin
%A Hahn, Wiebke
%A Lewerenz, Jan
%A Thaler, Franziska S
%A Korporal-Kuhnke, Mirjam
%A Melzer, Nico
%A Dargvainiene, Justina
%A Bien, Christian G
%A Kohlie, Rose
%A Lattwein, Erik
%A Schmitz, Dietmar
%A Calabresi, Peter A
%A Pardo, Carlos A
%A Prüss, Harald
%A Ruprecht, Klemens
%A Benjamin Larman, H.
%T Specific viral antibodies associate with anti-NMDAR encephalitis after herpes simplex encephalitis.
%J Brain, behavior and immunity
%V 130
%@ 0889-1591
%C Orlando, Fla. [u.a.]
%I Elsevier
%M DZNE-2025-01042
%P 106073
%D 2025
%X Herpes simplex encephalitis (HSE) patients may develop secondary anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis (NMDARE), associated with worsened long-term neurological outcome. Immunosuppressive treatment can limit NMDAR autoantibody-mediated pathology, but early predictive biomarkers for the risk of NMDARE are lacking. In a multicenter study, we performed unbiased antibody reactome profiling using Phage ImmunoPrecipitation Sequencing (PhIP-Seq). HSE patients with secondary NMDARE (n = 13) versus those without (n = 10) showed enhanced antibody responses against HSV-1, but not HSV-2, which comprised specific antibodies to five peptides of the HSV-1 UL42 and UL48 proteins. A score of these signature CSF antibodies identified HSE patients with secondary NMDARE with a sensitivity of 75
%K Antibody reactome (Other)
%K Encephalitis (Other)
%K HSE (Other)
%K HSV (Other)
%K Intrathecal synthesis (Other)
%K MICAR (Other)
%K NMDAR (Other)
%K PhIP-Seq (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40803454
%R 10.1016/j.bbi.2025.106073
%U https://pub.dzne.de/record/280960