TY - JOUR
AU - Kreye, Jakob
AU - Morgenlander, William R
AU - Thakar, Manjusha
AU - Schulte-Frankenfeld, Poul M
AU - Schott, Sarah
AU - Bünger, Isabel
AU - Kornau, Hans-Christian
AU - Angkeow, Julia W
AU - Jayaraman, Sahana
AU - Otto, Carolin
AU - Hahn, Wiebke
AU - Lewerenz, Jan
AU - Thaler, Franziska S
AU - Korporal-Kuhnke, Mirjam
AU - Melzer, Nico
AU - Dargvainiene, Justina
AU - Bien, Christian G
AU - Kohlie, Rose
AU - Lattwein, Erik
AU - Schmitz, Dietmar
AU - Calabresi, Peter A
AU - Pardo, Carlos A
AU - Prüss, Harald
AU - Ruprecht, Klemens
AU - Benjamin Larman, H.
TI - Specific viral antibodies associate with anti-NMDAR encephalitis after herpes simplex encephalitis.
JO - Brain, behavior and immunity
VL - 130
SN - 0889-1591
CY - Orlando, Fla. [u.a.]
PB - Elsevier
M1 - DZNE-2025-01042
SP - 106073
PY - 2025
AB - Herpes simplex encephalitis (HSE) patients may develop secondary anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis (NMDARE), associated with worsened long-term neurological outcome. Immunosuppressive treatment can limit NMDAR autoantibody-mediated pathology, but early predictive biomarkers for the risk of NMDARE are lacking. In a multicenter study, we performed unbiased antibody reactome profiling using Phage ImmunoPrecipitation Sequencing (PhIP-Seq). HSE patients with secondary NMDARE (n = 13) versus those without (n = 10) showed enhanced antibody responses against HSV-1, but not HSV-2, which comprised specific antibodies to five peptides of the HSV-1 UL42 and UL48 proteins. A score of these signature CSF antibodies identified HSE patients with secondary NMDARE with a sensitivity of 75
KW - Antibody reactome (Other)
KW - Encephalitis (Other)
KW - HSE (Other)
KW - HSV (Other)
KW - Intrathecal synthesis (Other)
KW - MICAR (Other)
KW - NMDAR (Other)
KW - PhIP-Seq (Other)
LB - PUB:(DE-HGF)16
C6 - pmid:40803454
DO - DOI:10.1016/j.bbi.2025.106073
UR - https://pub.dzne.de/record/280960
ER -