TY  - JOUR
AU  - Kreye, Jakob
AU  - Morgenlander, William R
AU  - Thakar, Manjusha
AU  - Schulte-Frankenfeld, Poul M
AU  - Schott, Sarah
AU  - Bünger, Isabel
AU  - Kornau, Hans-Christian
AU  - Angkeow, Julia W
AU  - Jayaraman, Sahana
AU  - Otto, Carolin
AU  - Hahn, Wiebke
AU  - Lewerenz, Jan
AU  - Thaler, Franziska S
AU  - Korporal-Kuhnke, Mirjam
AU  - Melzer, Nico
AU  - Dargvainiene, Justina
AU  - Bien, Christian G
AU  - Kohlie, Rose
AU  - Lattwein, Erik
AU  - Schmitz, Dietmar
AU  - Calabresi, Peter A
AU  - Pardo, Carlos A
AU  - Prüss, Harald
AU  - Ruprecht, Klemens
AU  - Benjamin Larman, H.
TI  - Specific viral antibodies associate with anti-NMDAR encephalitis after herpes simplex encephalitis.
JO  - Brain, behavior and immunity
VL  - 130
SN  - 0889-1591
CY  - Orlando, Fla. [u.a.]
PB  - Elsevier
M1  - DZNE-2025-01042
SP  - 106073
PY  - 2025
AB  - Herpes simplex encephalitis (HSE) patients may develop secondary anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis (NMDARE), associated with worsened long-term neurological outcome. Immunosuppressive treatment can limit NMDAR autoantibody-mediated pathology, but early predictive biomarkers for the risk of NMDARE are lacking. In a multicenter study, we performed unbiased antibody reactome profiling using Phage ImmunoPrecipitation Sequencing (PhIP-Seq). HSE patients with secondary NMDARE (n = 13) versus those without (n = 10) showed enhanced antibody responses against HSV-1, but not HSV-2, which comprised specific antibodies to five peptides of the HSV-1 UL42 and UL48 proteins. A score of these signature CSF antibodies identified HSE patients with secondary NMDARE with a sensitivity of 75
KW  - Antibody reactome (Other)
KW  - Encephalitis (Other)
KW  - HSE (Other)
KW  - HSV (Other)
KW  - Intrathecal synthesis (Other)
KW  - MICAR (Other)
KW  - NMDAR (Other)
KW  - PhIP-Seq (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40803454
DO  - DOI:10.1016/j.bbi.2025.106073
UR  - https://pub.dzne.de/record/280960
ER  -