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000280963 1001_ $$aLo, Hung$$b0
000280963 245__ $$aFeeding-induced olfactory cortex suppression reduces satiation.
000280963 260__ $$a[Cambridge, Mass.]$$bCell Press$$c2025
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000280963 520__ $$aBinge feeding commonly leads to overeating. Experiencing flavor during food consumption contributes to satiation. Still, the interactions between flavor, binge feeding, and food intake remain unknown. Using miniscopes for in vivo calcium imaging in the anterior piriform cortex (aPC) in freely moving mice, we identified specific excitatory neuronal responses to different food flavors during slow feeding. Switching from slow feeding to binge feeding transformed these specific responses into an unspecific global suppression of neuronal activity. Consummatory aPC suppression scaled with food value. GABAergic neurons in the olfactory tubercle (OT) projected to the aPC and mirrored activity patterns in the aPC under different feeding conditions, consistent with transmitting a value signal. Closed-loop optogenetic manipulations demonstrated that suppressing the aPC during binge bouts reduces satiation by selectively prolonging feeding bouts. We propose that aPC suppression by the OT enhances food intake by reducing sensory satiation during binge feeding-associated states of high motivation.
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000280963 650_7 $$2Other$$aCa(2+) imaging
000280963 650_7 $$2Other$$abinge eating
000280963 650_7 $$2Other$$aconsumption
000280963 650_7 $$2Other$$aflavor
000280963 650_7 $$2Other$$afunctional connectivity
000280963 650_7 $$2Other$$aolfactory tubercle
000280963 650_7 $$2Other$$aoptogenetics
000280963 650_7 $$2Other$$apiriform cortex
000280963 650_7 $$2Other$$asensory satiation
000280963 650_7 $$2Other$$asmell
000280963 7001_ $$aRiedel, Walter Cañedo$$b1
000280963 7001_ $$aTantirigama, Malinda L S$$b2
000280963 7001_ $$aSchoenherr, Anke$$b3
000280963 7001_ $$aMoreno Velasquez, Laura$$b4
000280963 7001_ $$0P:(DE-2719)9001061$$aFaiss, Lukas$$b5$$udzne
000280963 7001_ $$aKumar, Amit$$b6
000280963 7001_ $$0P:(DE-2719)9003240$$aHakus, Aileen$$b7$$udzne
000280963 7001_ $$0P:(DE-2719)2810914$$aRost, Benjamin R$$b8$$udzne
000280963 7001_ $$aLarkum, Matthew E$$b9
000280963 7001_ $$aJudkewitz, Benjamin$$b10
000280963 7001_ $$aStumpenhorst, Katharina$$b11
000280963 7001_ $$aRivalan, Marion$$b12
000280963 7001_ $$aWinter, York$$b13
000280963 7001_ $$aRusso, Eleonora$$b14
000280963 7001_ $$aKelsch, Wolfgang$$b15
000280963 7001_ $$0P:(DE-2719)2810725$$aSchmitz, Dietmar$$b16$$udzne
000280963 7001_ $$aJohenning, Friedrich W$$b17
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