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@ARTICLE{Lo:280963,
      author       = {Lo, Hung and Riedel, Walter Cañedo and Tantirigama,
                      Malinda L S and Schoenherr, Anke and Moreno Velasquez, Laura
                      and Faiss, Lukas and Kumar, Amit and Hakus, Aileen and Rost,
                      Benjamin R and Larkum, Matthew E and Judkewitz, Benjamin and
                      Stumpenhorst, Katharina and Rivalan, Marion and Winter, York
                      and Russo, Eleonora and Kelsch, Wolfgang and Schmitz,
                      Dietmar and Johenning, Friedrich W},
      title        = {{F}eeding-induced olfactory cortex suppression reduces
                      satiation.},
      journal      = {Neuron},
      volume       = {113},
      number       = {17},
      issn         = {0896-6273},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {DZNE-2025-01045},
      pages        = {2856-2871.e8},
      year         = {2025},
      abstract     = {Binge feeding commonly leads to overeating. Experiencing
                      flavor during food consumption contributes to satiation.
                      Still, the interactions between flavor, binge feeding, and
                      food intake remain unknown. Using miniscopes for in vivo
                      calcium imaging in the anterior piriform cortex (aPC) in
                      freely moving mice, we identified specific excitatory
                      neuronal responses to different food flavors during slow
                      feeding. Switching from slow feeding to binge feeding
                      transformed these specific responses into an unspecific
                      global suppression of neuronal activity. Consummatory aPC
                      suppression scaled with food value. GABAergic neurons in the
                      olfactory tubercle (OT) projected to the aPC and mirrored
                      activity patterns in the aPC under different feeding
                      conditions, consistent with transmitting a value signal.
                      Closed-loop optogenetic manipulations demonstrated that
                      suppressing the aPC during binge bouts reduces satiation by
                      selectively prolonging feeding bouts. We propose that aPC
                      suppression by the OT enhances food intake by reducing
                      sensory satiation during binge feeding-associated states of
                      high motivation.},
      keywords     = {Ca(2+) imaging (Other) / binge eating (Other) / consumption
                      (Other) / flavor (Other) / functional connectivity (Other) /
                      olfactory tubercle (Other) / optogenetics (Other) / piriform
                      cortex (Other) / sensory satiation (Other) / smell (Other)},
      cin          = {AG Schmitz},
      ddc          = {610},
      cid          = {I:(DE-2719)1810004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40818450},
      doi          = {10.1016/j.neuron.2025.07.020},
      url          = {https://pub.dzne.de/record/280963},
}