Home > Publications Database > Feeding-induced olfactory cortex suppression reduces satiation. > print

001     280963
005     20250921002011.0
024 7 _ |a 10.1016/j.neuron.2025.07.020
|2 doi
024 7 _ |a pmid:40818450
|2 pmid
024 7 _ |a 0896-6273
|2 ISSN
024 7 _ |a 1097-4199
|2 ISSN
024 7 _ |a altmetric:180340240
|2 altmetric
037 _ _ |a DZNE-2025-01045
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Lo, Hung
|b 0
245 _ _ |a Feeding-induced olfactory cortex suppression reduces satiation.
260 _ _ |a [Cambridge, Mass.]
|c 2025
|b Cell Press
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1758105666_31854
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Binge feeding commonly leads to overeating. Experiencing flavor during food consumption contributes to satiation. Still, the interactions between flavor, binge feeding, and food intake remain unknown. Using miniscopes for in vivo calcium imaging in the anterior piriform cortex (aPC) in freely moving mice, we identified specific excitatory neuronal responses to different food flavors during slow feeding. Switching from slow feeding to binge feeding transformed these specific responses into an unspecific global suppression of neuronal activity. Consummatory aPC suppression scaled with food value. GABAergic neurons in the olfactory tubercle (OT) projected to the aPC and mirrored activity patterns in the aPC under different feeding conditions, consistent with transmitting a value signal. Closed-loop optogenetic manipulations demonstrated that suppressing the aPC during binge bouts reduces satiation by selectively prolonging feeding bouts. We propose that aPC suppression by the OT enhances food intake by reducing sensory satiation during binge feeding-associated states of high motivation.
536 _ _ |a 351 - Brain Function (POF4-351)
|0 G:(DE-HGF)POF4-351
|c POF4-351
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a Ca(2+) imaging
|2 Other
650 _ 7 |a binge eating
|2 Other
650 _ 7 |a consumption
|2 Other
650 _ 7 |a flavor
|2 Other
650 _ 7 |a functional connectivity
|2 Other
650 _ 7 |a olfactory tubercle
|2 Other
650 _ 7 |a optogenetics
|2 Other
650 _ 7 |a piriform cortex
|2 Other
650 _ 7 |a sensory satiation
|2 Other
650 _ 7 |a smell
|2 Other
700 1 _ |a Riedel, Walter Cañedo
|b 1
700 1 _ |a Tantirigama, Malinda L S
|b 2
700 1 _ |a Schoenherr, Anke
|b 3
700 1 _ |a Moreno Velasquez, Laura
|b 4
700 1 _ |a Faiss, Lukas
|0 P:(DE-2719)9001061
|b 5
|u dzne
700 1 _ |a Kumar, Amit
|b 6
700 1 _ |a Hakus, Aileen
|0 P:(DE-2719)9003240
|b 7
|u dzne
700 1 _ |a Rost, Benjamin R
|0 P:(DE-2719)2810914
|b 8
|u dzne
700 1 _ |a Larkum, Matthew E
|b 9
700 1 _ |a Judkewitz, Benjamin
|b 10
700 1 _ |a Stumpenhorst, Katharina
|b 11
700 1 _ |a Rivalan, Marion
|b 12
700 1 _ |a Winter, York
|b 13
700 1 _ |a Russo, Eleonora
|b 14
700 1 _ |a Kelsch, Wolfgang
|b 15
700 1 _ |a Schmitz, Dietmar
|0 P:(DE-2719)2810725
|b 16
|u dzne
700 1 _ |a Johenning, Friedrich W
|b 17
773 _ _ |a 10.1016/j.neuron.2025.07.020
|g p. S0896627325005471
|0 PERI:(DE-600)2001944-0
|n 17
|p 2856-2871.e8
|t Neuron
|v 113
|y 2025
|x 0896-6273
856 4 _ |u https://pub.dzne.de/record/280963/files/DZNE-2025-01045%20SUP.zip
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/280963/files/DZNE-2025-01045.pdf
856 4 _ |u https://pub.dzne.de/record/280963/files/DZNE-2025-01045.pdf?subformat=pdfa
|x pdfa
|y OpenAccess
909 C O |o oai:pub.dzne.de:280963
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 5
|6 P:(DE-2719)9001061
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 7
|6 P:(DE-2719)9003240
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 8
|6 P:(DE-2719)2810914
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 16
|6 P:(DE-2719)2810725
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-351
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Brain Function
|x 0
914 1 _ |y 2025
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2024-12-27
915 _ _ |a IF >= 15
|0 StatID:(DE-HGF)9915
|2 StatID
|b NEURON : 2022
|d 2024-12-27
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b NEURON : 2022
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2024-12-27
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2024-12-27
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2024-12-27
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
|d 2024-12-27
|w ger
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2024-12-27
920 1 _ |0 I:(DE-2719)1810004
|k AG Schmitz
|l Network Dysfunction
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1810004
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21