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@ARTICLE{Akradi:280969,
      author       = {Akradi, Mohammad and Farzane-Daghigh, Tara and Ebneabbasi,
                      Amir and Bi, Hanwen and Drzezga, Alexander and Mander, Bryce
                      A and Eickhoff, Simon B and Tahmasian, Masoud},
      collaboration = {Initiative, Alzheimer’s Disease Neuroimaging},
      title        = {{H}ow is self-reported sleep-disordered breathing linked
                      with biomarkers of {A}lzheimer's disease?},
      journal      = {Neurobiology of aging},
      volume       = {154},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2025-01051},
      pages        = {16 - 24},
      year         = {2025},
      abstract     = {Sleep-disordered breathing (SDB) is prevalent in
                      Alzheimer's disease (AD). Here, we assessed how
                      self-reported SDB is linked with AD biomarkers, including
                      amyloid-beta plaque burden (Aβ), regional
                      fluorodeoxyglucose uptake (rFDG-PET), grey matter volume
                      (GMV), cognitive scores, and cerebrospinal fluid (CSF)
                      biomarkers. We selected 757 individuals, including AD, mild
                      cognitive impairment (MCI), and cognitively unimpaired (CU)
                      groups, and divided them according to self-reported SDB
                      condition. Using a stratified subsampling approach, we
                      selected 512 matched subsamples, and effect sizes (ES) of
                      the group-SDB interaction were computed for each biomarker
                      and cognitive score across subsamples. Linear regression
                      assessed associations between the ES of Aβ, rFDG, and GMV
                      with the ES of cognitive scores and CSF biomarkers. The
                      group-SDB interaction had a medium-sized effect on Aβ,
                      rFDG, and GMV biomarkers in several brain areas.
                      Participants with SDB exhibited reduced Aβ burden and
                      increased rFDG uptake in the CU and MCI groups, whereas the
                      AD group showed elevated Aβ burden and decreased rFDG.
                      Additionally, SDB+ individuals demonstrated GMV alterations
                      across all groups. The ES of group-SDB interaction on Aβ in
                      the precuneus, middle temporal gyrus, and fusiform gyrus was
                      associated with the ES of cognitive scores. Taken together,
                      we observed a robust association of SDB with Aβ pathology
                      in PET and CSF relative to rFDG and GMV in the AD group,
                      which was also associated with cognitive decline.},
      keywords     = {Alzheimer’s disease (Other) / Amyloid-beta (Other) /
                      Fluorodeoxyglucose imaging (Other) / Grey matter volume
                      (Other) / Sleep-disordered breathing (Other)},
      cin          = {AG Boecker},
      ddc          = {610},
      cid          = {I:(DE-2719)1011202},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40582243},
      doi          = {10.1016/j.neurobiolaging.2025.06.006},
      url          = {https://pub.dzne.de/record/280969},
}