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@ARTICLE{Arndt:280971,
      author       = {Arndt, Philipp and Boewe, Stefanie and Brüggemann, Jascha
                      and Garcia-Garcia, Berta and Yakupov, Renat and Vockert,
                      Niklas and Maas, Anne and Pfister, Malte and Perosa,
                      Valentina and Dubai, Marwa Al and Jansen, Robin and Meuth,
                      Sven G and Dörner, Marc and Müller, Patrick and Henneicke,
                      Solveig and Schreiber, Frank and Neumann, Katja and Mattern,
                      Hendrik and Schreiber, Stefanie},
      title        = {{P}utamen vascularization on high-resolution 7{T} {MRI} is
                      associated with perfusion and cognitive performance in
                      cerebral small vessel disease.},
      journal      = {NeuroImage},
      volume       = {319},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2025-01053},
      pages        = {121426},
      year         = {2025},
      abstract     = {In cerebral small vessel disease (CSVD), compromised
                      arterial supply to the deep gray matter contributes to
                      cognitive decline. While CSVD frequently involves
                      lenticulostriate arteries supplying the putamen, the
                      functional consequences of altered putaminal vascular
                      architecture remain unclear. We hypothesized that a less
                      homogeneous arterial network in the putamen is associated
                      with impaired perfusion and worse cognitive performance in
                      CSVD.We enrolled 16 CSVD patients with cerebral microbleeds
                      and 21 age‑matched controls (mean age 71 years; 38 $\%$
                      female). High-resolution 7 T time‑of‑flight angiography
                      was used to segment all visible intraputaminal vessels. For
                      each voxel in the putamen, the distance to its nearest
                      segmented vessel was computed to generate a vessel distance
                      map; the mean vessel distance reflects the homogeneity of
                      the arterial network. Putaminal perfusion was quantified via
                      multi‑inversion time pulsed arterial spin labeling (ASL)
                      at 3 T, and CSVD severity was scored on clinical 3 T MRI.
                      All participants completed a comprehensive
                      neuropsychological battery to derive a global cognition
                      composite score.Linear regression revealed that higher CSVD
                      MRI scores predicted larger mean vessel distance, reflecting
                      a sparser arterial network, in both the right (B = 0.12, β
                      = 0.42, p = 0.010) and left putamen (B = 0.13, β = 0.43, p
                      = 0.014). Across all participants, increased vessel distance
                      was also associated with prolonged arterial transit time in
                      the right (B = 0.044, β = 0.50, p = 0.009) and left putamen
                      (B = 0.042, β = 0.49, p = 0.009). Finally, in a
                      multivariable linear regression adjusting for demographics,
                      vascular risk factors, and CSVD severity, greater vessel
                      distance in the right putamen was associated with lower
                      global cognitive performance (B = -1.26, β = -0.34, p =
                      0.012).This study demonstrates the impact of an impaired
                      arterial network in the putamen on blood supply and
                      cognitive function across the continuum of CSVD.},
      keywords     = {Arterial spin labelling (Other) / Basal ganglia (Other) /
                      Cerebral small vessel disease (Other) / Cognition (Other) /
                      Lenticulostriate arteries (Other) / Putamen (Other) / Vessel
                      distance mapping (Other)},
      cin          = {AG Schreiber / AG Düzel / AG Maaß},
      ddc          = {610},
      cid          = {I:(DE-2719)1310010 / I:(DE-2719)5000006 /
                      I:(DE-2719)1311001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40850635},
      doi          = {10.1016/j.neuroimage.2025.121426},
      url          = {https://pub.dzne.de/record/280971},
}