TY  - JOUR
AU  - Platen, Moritz
AU  - Buchholz, Maresa
AU  - Rädke, Anika
AU  - Glaeser, Eva
AU  - Iskandar, Audrey
AU  - van den Berg, Neeltje
AU  - Hoffmann, Wolfgang
AU  - Michalowsky, Bernhard
TI  - Differentiation Between Early and Severe Stages of Dementia in Claims Data Based on Diagnosis, Prescription, and Utilization Patterns.
JO  - Neurology and Therapy
VL  - 14
IS  - 4
SN  - 2193-6536
CY  - Heidelberg [u.a.]
PB  - Springer
M1  - DZNE-2025-01057
SP  - 1589 - 1608
PY  - 2025
AB  - Claims data typically lack clinical parameters such as dementia severity, limiting insights into disease progression and related healthcare utilization and costs. Although diagnoses, prescriptions, and utilization patterns may serve as proxies, their validity is unclear. This study aimed to identify and validate these parameters to distinguish early from severe dementia stages.Baseline data from 737 patients with dementia were analyzed. Dementia severity was assessed using the Mini-Mental State Examination and classified as early (≥ 27), mild (20-26), and moderate to severe (0-19). Healthcare utilization was recorded via structured interviews. Diagnoses, long-term care levels, and prescribed medications were extracted from physicians' files. Ordinal logistic regression evaluated associations between predictors and severity, with average marginal effects (AME) quantifying impact. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were computed for key predictors.Among the sample (56
KW  - Alzheimer’s disease (Other)
KW  - Antidementia drug treatment (Other)
KW  - Antipsychotics (Other)
KW  - Claims data (Other)
KW  - Dementia (Other)
KW  - Dementia severity (Other)
KW  - Healthcare utilization (Other)
KW  - Real-world data (Other)
KW  - Real-world evidence (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40504345
C2  - pmc:PMC12255591
DO  - DOI:10.1007/s40120-025-00778-y
UR  - https://pub.dzne.de/record/280975
ER  -