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@ARTICLE{Gelfert:280976,
      author       = {Gelfert, Gloria G and Grittner, Ulrike and Kuhnert, Ronny
                      and Scheidt-Nave, Christa and Endres, Matthias and Nave,
                      Alexander H},
      title        = {{A}ssociation of {L}ipoprotein(a) {W}ith {C}ardiovascular
                      and {C}erebrovascular {D}isease in a {N}ationally
                      {R}epresentative {C}ohort of {G}ermany.},
      journal      = {JACC: advances},
      volume       = {4},
      number       = {8},
      issn         = {2772-963X},
      address      = {[Amsterdam]},
      publisher    = {Elsevier B.V.},
      reportid     = {DZNE-2025-01058},
      pages        = {102015},
      year         = {2025},
      abstract     = {Population-based data on the distribution of lipoprotein(a)
                      (Lp[a]) within the German population are lacking.The aim of
                      the study was to determine the age- and sex-specific Lp(a)
                      distribution in Germany and analyze its association with
                      different types of cardiovascular disease (CVD).We analyzed
                      cross-sectional data from the German National Health
                      Interview and Examination Survey 1998, a population-based
                      study representing the German adult population's health
                      status from 1997 to 1999. We examined serum Lp(a) according
                      to demographics and investigated associations between Lp(a)
                      and history of self-reported CVD. We tested Lp(a) in spline
                      analysis on continuous scales and as dichotomous Lp(a)
                      thresholds.In the German National Health Interview and
                      Examination Survey 1998 (n = 6,657), median Lp(a) was 15.3
                      mg/dL (Q1-Q3: 5.6, 43.1). Lp(a) levels ≥50 mg/dL were
                      present in $21.6\%.$ Men had substantially higher median
                      Lp(a) than women (22.1 mg/dL vs 10.3 mg/dL). Median Lp(a)
                      levels were significantly higher in individuals with than
                      without a history of atherosclerotic cardiovascular disease
                      (ASCVD) but did not significantly differ between people with
                      and without venous thrombosis. In logistic regression
                      analysis with splines, higher Lp(a) levels were associated
                      with a higher probability of a history of CVD. In logistic
                      regression analyses, Lp(a) ≥50 mg/dL was associated with a
                      history of ASCVD (OR: 1.36 $[95\%$ CI: 1.04-1.78]; P =
                      0.023).About 1 in 5 German individuals from a prestatin era
                      population had Lp(a) levels ≥50 mg/dL. Higher levels were
                      independently associated with ASCVD, but not with venous
                      thrombosis. These findings provide a basis for future
                      prospective studies to define the role of Lp(a) in CVD risk
                      in the German population.},
      keywords     = {cardiovascular disease (Other) / cardiovascular risk
                      (Other) / epidemiology (Other) / lipoprotein(a) (Other) /
                      prevention (Other) / venous thrombosis (Other)},
      cin          = {AG Endres},
      ddc          = {610},
      cid          = {I:(DE-2719)1811005},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40706144},
      pmc          = {pmc:PMC12309279},
      doi          = {10.1016/j.jacadv.2025.102015},
      url          = {https://pub.dzne.de/record/280976},
}