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@ARTICLE{Bayar:280977,
      author       = {Bayar, Seyhmus and Seep, Lea and Doubková, Karolína and
                      Zurkovic, Jelena and Bülow, Margret H and Kierdorf, Katrin
                      and Bauer, Reinhard and Thiele, Christoph and Tavosanis,
                      Gaia and Hasenauer, Jan and Mass, Elvira},
      title        = {{D}evelopmental programming by maternal obesity alters
                      offspring lifespan and immune responses in a diet- and
                      sex-specific manner.},
      journal      = {Cells $\&$ development},
      volume       = {183},
      issn         = {2667-2901},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-01059},
      pages        = {204040},
      year         = {2025},
      abstract     = {Maternal obesity is a growing health concern that
                      predisposes offspring to metabolic dysfunction, immune
                      system alterations, and neurodegenerative disorders. To
                      investigate the intergenerational effects of maternal
                      obesity, we used Drosophila melanogaster exposed to
                      high-sugar (HSD) and high-fat diets (HFD) before mating. We
                      found that maternal diet-induced obesity significantly
                      altered offspring lifespan, immune responses, and neuronal
                      health in a sex- and diet-specific manner. Male offspring
                      were particularly susceptible, exhibiting reduced lifespan,
                      impaired climbing ability, and increased axonal
                      degeneration, especially following maternal HFD exposure.
                      Transcriptomic analyses revealed age-dependent and
                      diet-specific changes, with males showing pronounced
                      alterations at 50 days of age. Developmental programming of
                      hemocytes (blood-like cells) played a crucial role in these
                      outcomes, as knockdown of key immune pathways such as Relish
                      and upd3 in hemocytes further influenced lifespan in a
                      diet-specific manner. These findings highlight the complex
                      interplay between maternal diet and immune function,
                      underscoring the impact of maternal obesity-induced
                      imprinting on immune cells and subsequent long-term health
                      consequences. Our study provides new insights into conserved
                      mechanisms linking maternal metabolic health to offspring
                      outcomes and emphasizes the continued need for animal models
                      to understand intergenerational health impacts.},
      keywords     = {Developmental reprogramming (Other) / Drosophila
                      melanogaster (Other) / Hemocytes (Other) / Lifespan (Other)
                      / Macrophages (Other) / Maternal obesity (Other) /
                      Metabolism (Other) / Neurodegeneration (Other) /
                      Plasmatocytes (Other)},
      cin          = {AG Tavosanis},
      ddc          = {610},
      cid          = {I:(DE-2719)1013018},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40653017},
      doi          = {10.1016/j.cdev.2025.204040},
      url          = {https://pub.dzne.de/record/280977},
}