%0 Journal Article
%A Filler, Jule
%A Georgakis, Marios K
%A Janowitz, Daniel
%A Duering, Marco
%A Fang, Rong
%A Dewenter, Anna
%A Bode, Felix J
%A Stoesser, Sebastian
%A Kindler, Christine
%A Hermann, Peter
%A Nolte, Christian
%A Liman, Thomas G
%A Kerti, Lucia
%A Bernkopf, Kathleen
%A Ikenberg, Benno
%A Glanz, Wenzel
%A Wagner, Michael
%A Spottke, Annika
%A Waegemann, Karin
%A Goertler, Michael
%A Wunderlich, Silke
%A Endres, Matthias
%A Zerr, Inga
%A Petzold, Gabor C
%A Dichgans, Martin
%T Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study.
%J The lancet / Regional health. Europe
%V 56
%@ 2666-7762
%C [Amsterdam]
%I Elsevier
%M DZNE-2025-01060
%P 101428
%D 2025
%X Stroke survivors frequently experience subsequent cognitive impairment or dementia. We aimed to identify risk factors for post-stroke dementia (PSD) and cognitive impairment (PSCI) within 5 years after stroke.The DEMDAS (German Center for Neurological Diseases (DZNE) mechanisms of dementia after stroke) study is a prospective cohort of stroke patients admitted to six German tertiary stroke centres between May 1, 2011 and January 31, 2019. Eligible dementia-free patients with ischaemic or haemorrhagic stroke underwent baseline examinations and regular clinical, neuropsychological, and neuroimaging follow-ups over 5 years, with the last follow-ups completed in January 2024. PSD was the primary outcome, determined by comprehensive cognitive testing, patient and informant interviews, and review of medical records. The secondary outcomes were early-onset PSD (3-6 months), delayed-onset PSD (>6 months), and PSCI. Associations between baseline risk factors and PSD were assessed using Cox regression models adjusted for age, sex, education, and stroke severity.Of 736 patients (245 [33
%K Brain ischaemia (Other)
%K Cognitive decline (Other)
%K Dementia (Other)
%K Dementia epidemiology (Other)
%K Diabetes (Other)
%K Metabolic syndrome (Other)
%K Post-stroke cognitive impairment (Other)
%K Post-stroke dementia (Other)
%K Risk factors (Other)
%K Small vessel disease (Other)
%K Stroke (Other)
%K Stroke epidemiology (Other)
%K Stroke outcomes (Other)
%K Vascular dementia (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40893447
%2 pmc:PMC12396445
%R 10.1016/j.lanepe.2025.101428
%U https://pub.dzne.de/record/280978