TY  - JOUR
AU  - Filler, Jule
AU  - Georgakis, Marios K
AU  - Janowitz, Daniel
AU  - Duering, Marco
AU  - Fang, Rong
AU  - Dewenter, Anna
AU  - Bode, Felix J
AU  - Stoesser, Sebastian
AU  - Kindler, Christine
AU  - Hermann, Peter
AU  - Nolte, Christian
AU  - Liman, Thomas G
AU  - Kerti, Lucia
AU  - Bernkopf, Kathleen
AU  - Ikenberg, Benno
AU  - Glanz, Wenzel
AU  - Wagner, Michael
AU  - Spottke, Annika
AU  - Waegemann, Karin
AU  - Goertler, Michael
AU  - Wunderlich, Silke
AU  - Endres, Matthias
AU  - Zerr, Inga
AU  - Petzold, Gabor C
AU  - Dichgans, Martin
TI  - Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study.
JO  - The lancet / Regional health. Europe
VL  - 56
SN  - 2666-7762
CY  - [Amsterdam]
PB  - Elsevier
M1  - DZNE-2025-01060
SP  - 101428
PY  - 2025
AB  - Stroke survivors frequently experience subsequent cognitive impairment or dementia. We aimed to identify risk factors for post-stroke dementia (PSD) and cognitive impairment (PSCI) within 5 years after stroke.The DEMDAS (German Center for Neurological Diseases (DZNE) mechanisms of dementia after stroke) study is a prospective cohort of stroke patients admitted to six German tertiary stroke centres between May 1, 2011 and January 31, 2019. Eligible dementia-free patients with ischaemic or haemorrhagic stroke underwent baseline examinations and regular clinical, neuropsychological, and neuroimaging follow-ups over 5 years, with the last follow-ups completed in January 2024. PSD was the primary outcome, determined by comprehensive cognitive testing, patient and informant interviews, and review of medical records. The secondary outcomes were early-onset PSD (3-6 months), delayed-onset PSD (>6 months), and PSCI. Associations between baseline risk factors and PSD were assessed using Cox regression models adjusted for age, sex, education, and stroke severity.Of 736 patients (245 [33
KW  - Brain ischaemia (Other)
KW  - Cognitive decline (Other)
KW  - Dementia (Other)
KW  - Dementia epidemiology (Other)
KW  - Diabetes (Other)
KW  - Metabolic syndrome (Other)
KW  - Post-stroke cognitive impairment (Other)
KW  - Post-stroke dementia (Other)
KW  - Risk factors (Other)
KW  - Small vessel disease (Other)
KW  - Stroke (Other)
KW  - Stroke epidemiology (Other)
KW  - Stroke outcomes (Other)
KW  - Vascular dementia (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40893447
C2  - pmc:PMC12396445
DO  - DOI:10.1016/j.lanepe.2025.101428
UR  - https://pub.dzne.de/record/280978
ER  -