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000281102 1001_ $$0P:(DE-2719)9001409$$aSegen, Vladislava$$b0$$eFirst author
000281102 245__ $$aPath integration impairments reveal early cognitive changes in subjective cognitive decline.
000281102 260__ $$aWashington, DC [u.a.]$$bAssoc.$$c2025
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000281102 520__ $$aPath integration, the ability to track one's position using self-motion cues, is critically dependent on the grid cell network in the entorhinal cortex, a region vulnerable to early Alzheimer's disease pathology. In this study, we examined path integration performance in individuals with subjective cognitive decline (SCD), a group at increased risk for Alzheimer's disease, and healthy controls using an immersive virtual reality task. We developed a Bayesian computational model to decompose path integration errors into distinct components. SCD participants exhibited significantly higher path integration error, primarily driven by increased memory leak, while other modeling-derived error sources, such as velocity gain, sensory, and reporting noise, remained comparable across groups. Our findings suggest that path integration deficits, specifically memory leak, may serve as an early marker of neurodegeneration in SCD and highlight the potential of self-motion-based navigation tasks for detecting presymptomatic Alzheimer's disease-related cognitive changes.
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000281102 650_2 $$2MeSH$$aHumans
000281102 650_2 $$2MeSH$$aCognitive Dysfunction: physiopathology
000281102 650_2 $$2MeSH$$aCognitive Dysfunction: diagnosis
000281102 650_2 $$2MeSH$$aMale
000281102 650_2 $$2MeSH$$aFemale
000281102 650_2 $$2MeSH$$aAged
000281102 650_2 $$2MeSH$$aBayes Theorem
000281102 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000281102 650_2 $$2MeSH$$aCognition
000281102 650_2 $$2MeSH$$aEntorhinal Cortex: physiopathology
000281102 650_2 $$2MeSH$$aMiddle Aged
000281102 650_2 $$2MeSH$$aVirtual Reality
000281102 650_2 $$2MeSH$$aCase-Control Studies
000281102 7001_ $$aKabir, Md Rysul$$b1
000281102 7001_ $$aStreck, Adam$$b2
000281102 7001_ $$00000-0001-6465-663X$$aSlavik, Jakub$$b3
000281102 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b4
000281102 7001_ $$0P:(DE-2719)9001011$$aButryn, Michaela$$b5$$udzne
000281102 7001_ $$00000-0001-7006-4112$$aNewman, Ehren$$b6
000281102 7001_ $$aTiganj, Zoran$$b7
000281102 7001_ $$0P:(DE-2719)2810583$$aWolbers, Thomas$$b8$$eLast author
000281102 773__ $$0PERI:(DE-600)2810933-8$$a10.1126/sciadv.adw6404$$gVol. 11, no. 36, p. eadw6404$$n36$$peadw6404$$tScience advances$$v11$$x2375-2548$$y2025
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