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001     281102
005     20250924102922.0
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100 1 _ |a Segen, Vladislava
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245 _ _ |a Path integration impairments reveal early cognitive changes in subjective cognitive decline.
260 _ _ |a Washington, DC [u.a.]
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520 _ _ |a Path integration, the ability to track one's position using self-motion cues, is critically dependent on the grid cell network in the entorhinal cortex, a region vulnerable to early Alzheimer's disease pathology. In this study, we examined path integration performance in individuals with subjective cognitive decline (SCD), a group at increased risk for Alzheimer's disease, and healthy controls using an immersive virtual reality task. We developed a Bayesian computational model to decompose path integration errors into distinct components. SCD participants exhibited significantly higher path integration error, primarily driven by increased memory leak, while other modeling-derived error sources, such as velocity gain, sensory, and reporting noise, remained comparable across groups. Our findings suggest that path integration deficits, specifically memory leak, may serve as an early marker of neurodegeneration in SCD and highlight the potential of self-motion-based navigation tasks for detecting presymptomatic Alzheimer's disease-related cognitive changes.
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: physiopathology
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650 _ 2 |a Cognitive Dysfunction: diagnosis
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Aged
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650 _ 2 |a Bayes Theorem
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650 _ 2 |a Alzheimer Disease: physiopathology
|2 MeSH
650 _ 2 |a Cognition
|2 MeSH
650 _ 2 |a Entorhinal Cortex: physiopathology
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Virtual Reality
|2 MeSH
650 _ 2 |a Case-Control Studies
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700 1 _ |a Kabir, Md Rysul
|b 1
700 1 _ |a Streck, Adam
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700 1 _ |a Slavik, Jakub
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700 1 _ |a Glanz, Wenzel
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700 1 _ |a Butryn, Michaela
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700 1 _ |a Newman, Ehren
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700 1 _ |a Tiganj, Zoran
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700 1 _ |a Wolbers, Thomas
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773 _ _ |a 10.1126/sciadv.adw6404
|g Vol. 11, no. 36, p. eadw6404
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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