%0 Journal Article
%A Lungu, Ruxanda
%A Fernandes, Francisca F
%A Pires Monteiro, Sara
%A Outeiro, Tiago F
%A Shemesh, Noam
%T Neural and vascular contributions to sensory impairments in a human alpha-synuclein transgenic mouse model of Parkinson's disease.
%J Journal of cerebral blood flow & metabolism
%V 45
%N 9
%@ 0271-678X
%C London
%I Sage
%M DZNE-2025-01070
%P 1654 - 1669
%D 2025
%X Parkinson's disease (PD) is a complex progressive neurodegenerative disorder involving hallmarks such as α-Synuclein (αSyn) aggregation and dopaminergic dysfunction that affect brain-wide neural activity. Although movement disorders are prominent in PD, sensory impairments also occur relatively early on, mainly in olfactory and, to a lesser extent visual systems. While these deficits have been described mainly at the behavioral and molecular levels, the underlying network-level activity remains poorly understood. Here, we harnessed a human αSyn transgenic mouse model of PD with in vivo functional MRI (fMRI) to map evoked activity in the visual and olfactory pathways, along with pseudo-Continuous Arterial Spin Labeling (pCASL) and c-FOS measurements to disentangle vascular from neuronal effects. Upon stimulation with either odors or flickering lights, we found significant decreases in fMRI responses along both olfactory and visual pathways, in multiple cortical and subcortical sensory areas. Average Cerebral Blood Flow rates were decreased by ∼10
%K Animals
%K Mice, Transgenic
%K alpha-Synuclein: genetics
%K alpha-Synuclein: metabolism
%K Humans
%K Mice
%K Magnetic Resonance Imaging
%K Parkinson Disease: physiopathology
%K Parkinson Disease: genetics
%K Parkinson Disease: complications
%K Parkinson Disease: diagnostic imaging
%K Disease Models, Animal
%K Male
%K Cerebrovascular Circulation
%K Olfactory Pathways: physiopathology
%K Visual Pathways: physiopathology
%K Proto-Oncogene Proteins c-fos: metabolism
%K Brain: blood supply
%K ASL (Other)
%K Parkinson’s disease (Other)
%K c-FOS (Other)
%K fMRI (Other)
%K α-Synuclein (Other)
%K alpha-Synuclein (NLM Chemicals)
%K SNCA protein, human (NLM Chemicals)
%K Proto-Oncogene Proteins c-fos (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40334688
%2 pmc:PMC12058711
%R 10.1177/0271678X251338952
%U https://pub.dzne.de/record/281109