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000281110 1001_ $$0P:(DE-2719)9000645$$aLiu, Peng$$b0$$eFirst author
000281110 245__ $$aLayer-specific changes in sensory cortex across the lifespan in mice and humans.
000281110 260__ $$aNew York, NY$$bNature America$$c2025
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000281110 520__ $$aThe segregation of processes into cortical layers is a convergent feature in animal evolution. However, how changes in the cortical layer architecture interact with sensory system function and dysfunction remains unclear. Here we conducted functional and structural layer-specific in vivo 7T magnetic resonance imaging of the primary somatosensory cortex in two cohorts of healthy younger and older adults. Input layer IV is enlarged and more myelinated in older adults and is associated with extended sensory input signals. Age-related cortical thinning is driven by deep layers and accompanied by increased myelination, but there is no clear evidence for reduced inhibition. Calcium imaging and histology in younger and older mice revealed increased sensory-evoked neuronal activity accompanied by increased parvalbumin expression as a potential inhibitory balance, with dynamic changes in layer-specific myelination across age groups. Using multimodal imaging, we demonstrate that middle and deep layers show specific sensitivity to aging across species.
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000281110 650_7 $$2NLM Chemicals$$aParvalbumins
000281110 650_2 $$2MeSH$$aAnimals
000281110 650_2 $$2MeSH$$aSomatosensory Cortex: physiology
000281110 650_2 $$2MeSH$$aSomatosensory Cortex: diagnostic imaging
000281110 650_2 $$2MeSH$$aMice
000281110 650_2 $$2MeSH$$aHumans
000281110 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000281110 650_2 $$2MeSH$$aMale
000281110 650_2 $$2MeSH$$aAdult
000281110 650_2 $$2MeSH$$aFemale
000281110 650_2 $$2MeSH$$aAging: physiology
000281110 650_2 $$2MeSH$$aAging: pathology
000281110 650_2 $$2MeSH$$aYoung Adult
000281110 650_2 $$2MeSH$$aAged
000281110 650_2 $$2MeSH$$aMiddle Aged
000281110 650_2 $$2MeSH$$aMice, Inbred C57BL
000281110 650_2 $$2MeSH$$aParvalbumins: metabolism
000281110 7001_ $$0P:(DE-2719)2812088$$aDoehler, Juliane$$b1$$eFirst author
000281110 7001_ $$0P:(DE-2719)2813276$$aHenschke, Julia$$b2$$udzne
000281110 7001_ $$0P:(DE-2719)9000681$$aNorthall, Alicia$$b3$$udzne
000281110 7001_ $$00000-0003-1468-6448$$aKnaf-Serian, Angela$$b4
000281110 7001_ $$aLoaiza-Carvajal, Laura C$$b5
000281110 7001_ $$aBudinger, Eike$$b6
000281110 7001_ $$00000-0003-3686-1622$$aSchwarzkopf, Dietrich S$$b7
000281110 7001_ $$0P:(DE-2719)2810706$$aSpeck, Oliver$$b8$$udzne
000281110 7001_ $$0P:(DE-2719)2813669$$aPakan, Janelle M P$$b9
000281110 7001_ $$0P:(DE-2719)9001179$$aKuehn, Esther$$b10$$eLast author$$udzne
000281110 773__ $$0PERI:(DE-600)1494955-6$$a10.1038/s41593-025-02013-1$$gVol. 28, no. 9, p. 1978 - 1989$$n9$$p1978 - 1989$$tNature neuroscience$$v28$$x1097-6256$$y2025
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