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@ARTICLE{Liu:281110,
      author       = {Liu, Peng and Doehler, Juliane and Henschke, Julia and
                      Northall, Alicia and Knaf-Serian, Angela and
                      Loaiza-Carvajal, Laura C and Budinger, Eike and Schwarzkopf,
                      Dietrich S and Speck, Oliver and Pakan, Janelle M P and
                      Kuehn, Esther},
      title        = {{L}ayer-specific changes in sensory cortex across the
                      lifespan in mice and humans.},
      journal      = {Nature neuroscience},
      volume       = {28},
      number       = {9},
      issn         = {1097-6256},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {DZNE-2025-01071},
      pages        = {1978 - 1989},
      year         = {2025},
      abstract     = {The segregation of processes into cortical layers is a
                      convergent feature in animal evolution. However, how changes
                      in the cortical layer architecture interact with sensory
                      system function and dysfunction remains unclear. Here we
                      conducted functional and structural layer-specific in vivo
                      7T magnetic resonance imaging of the primary somatosensory
                      cortex in two cohorts of healthy younger and older adults.
                      Input layer IV is enlarged and more myelinated in older
                      adults and is associated with extended sensory input
                      signals. Age-related cortical thinning is driven by deep
                      layers and accompanied by increased myelination, but there
                      is no clear evidence for reduced inhibition. Calcium imaging
                      and histology in younger and older mice revealed increased
                      sensory-evoked neuronal activity accompanied by increased
                      parvalbumin expression as a potential inhibitory balance,
                      with dynamic changes in layer-specific myelination across
                      age groups. Using multimodal imaging, we demonstrate that
                      middle and deep layers show specific sensitivity to aging
                      across species.},
      keywords     = {Animals / Somatosensory Cortex: physiology / Somatosensory
                      Cortex: diagnostic imaging / Mice / Humans / Magnetic
                      Resonance Imaging / Male / Adult / Female / Aging:
                      physiology / Aging: pathology / Young Adult / Aged / Middle
                      Aged / Mice, Inbred C57BL / Parvalbumins: metabolism /
                      Parvalbumins (NLM Chemicals)},
      cin          = {AG Gasser / AG Düzel / AG Speck},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000 / I:(DE-2719)5000006 /
                      I:(DE-2719)1340009},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40790266},
      doi          = {10.1038/s41593-025-02013-1},
      url          = {https://pub.dzne.de/record/281110},
}