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@ARTICLE{Rysop:281111,
      author       = {Rysop, Anna Uta and Schiwek, Roxana and Grewe, Tanja and
                      Breitenstein, Caterina and Binkofski, Ferdinand and Roheger,
                      Mandy and Unger, Nina and Flöel, Agnes and Meinzer, Marcus},
      title        = {{P}articipatory {D}evelopment of a {S}peech-{L}anguage
                      {T}elerehabilitation {I}ntervention {C}ombined {W}ith
                      {H}ome-{B}ased {T}ranscranial {D}irect {C}urrent
                      {S}timulation for {P}rimary {P}rogressive {A}phasia: {A}
                      {Q}ualitative {S}tudy.},
      journal      = {American journal of speech-language pathology},
      volume       = {34},
      number       = {5},
      issn         = {1058-0360},
      address      = {Rockville, MD},
      publisher    = {American Speech-Language-Hearing Association},
      reportid     = {DZNE-2025-01072},
      pages        = {2760 - 2779},
      year         = {2025},
      abstract     = {Intensive speech-language therapy (SLT) delivered as
                      telerehabilitation in combination with transcranial direct
                      current stimulation (tDCS) may be an effective treatment
                      option for people with primary progressive aphasia (pwPPA).
                      However, such combined treatment approaches are technically
                      challenging, and feasibility for pwPPA has not yet been
                      established. We aimed to involve stakeholders in the
                      development of a novel approach combining remotely
                      supervised but independently self-administered home-based
                      tDCS with an intensive aphasia telerehabilitation (naming
                      and communicative-pragmatic therapy).Eight pwPPA (logopenic
                      variant: n = 5, nonfluent agrammatic variant: n = 1, not
                      specified variant: n = 2) and 16 caregivers participated in
                      two semistructured interviews to identify the needs,
                      preferences, and perceived barriers and challenges with
                      regard to SLT, telerehabilitation, and tDCS and the
                      combination of all components. Based on the results, a
                      step-by-step manual was developed and tested by means of
                      home-based usability tests and follow-up interviews
                      involving four dyads (logopenic variant: n = 4). Interview
                      data were transcribed and analyzed qualitatively and
                      quantitatively. Competency checklists used in the usability
                      tests were analyzed quantitatively.pwPPA and their
                      caregivers provided valuable insights into all aspects of
                      the planned treatment program. Overall, the findings suggest
                      a high level of acceptance and perceived need for an
                      intensive telerehabilitation SLT approach combined with
                      tDCS. Using the developed step-by-step manual and training,
                      pwPPA were able to independently perform more than half of
                      the actions required for telerehabilitation but needed
                      assistance with technically more demanding aspects of tDCS.
                      To ensure feasibility, caregiver assistance is needed to
                      support pwPPA during technically challenging
                      interventions.This mixed-methods study identified needs and
                      preferences of pwPPA and their caregivers with regard to
                      speech-language telerehabilitation, as well as barriers and
                      challenges regarding telerehabilitation and home-based tDCS.
                      We demonstrate high acceptability and initial feasibility of
                      such combined programs. Our findings highlight the
                      importance of stakeholder involvement in intervention
                      development, which will inform future development and
                      optimization of technologically demanding intervention
                      programs.https://doi.org/10.23641/asha.29906063.},
      keywords     = {Humans / Transcranial Direct Current Stimulation: methods /
                      Telerehabilitation / Female / Male / Aged / Middle Aged /
                      Qualitative Research / Speech Therapy: methods / Aphasia,
                      Primary Progressive: rehabilitation / Aphasia, Primary
                      Progressive: therapy / Aphasia, Primary Progressive:
                      diagnosis / Aphasia, Primary Progressive: psychology /
                      Language Therapy: methods / Caregivers: psychology /
                      Treatment Outcome / Combined Modality Therapy / Aged, 80 and
                      over},
      cin          = {AG Flöel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000081},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40844916},
      doi          = {10.1044/2025_AJSLP-24-00557},
      url          = {https://pub.dzne.de/record/281111},
}