%0 Journal Article
%A Kancheva, Ivana Kirilova
%A Bouzigues, Arabella
%A Russell, Lucy Louise
%A Foster, Phoebe H
%A Ferry-Bolder, Eve
%A Van Swieten, John C
%A Jiskoot, Lize Corrine
%A Seelaar, Harro
%A Sánchez-Valle, Raquel
%A Laforce, Robert
%A Graff, Caroline
%A Galimberti, Daniela
%A Vandenberghe, Rik
%A de Mendonça, Alexandre
%A Tiraboschi, Pietro
%A Santana, Isabel
%A Gerhard, Alexander
%A Levin, Johannes
%A Sorbi, Sandro
%A Otto, Markus
%A Ducharme, Simon
%A Butler, Christopher
%A Le Ber, Isabelle
%A Finger, Elizabeth
%A Tartaglia, Maria Carmela
%A Masellis, Mario
%A Synofzik, Matthis
%A Moreno, Fermin
%A Borroni, Barbara
%A Rohrer, Jonathan Daniel
%A van der Weerd, Louise
%A Rowe, James B
%A Tsvetanov, Kamen
%T Cerebrovascular Reactivity at Rest and Its Association With Cognitive Function in People With Genetic Frontotemporal Dementia.
%J Neurology
%V 105
%N 6
%@ 0028-3878
%C Philadelphia, Pa.
%I Wolters Kluwer
%M DZNE-2025-01074
%P e213677
%D 2025
%X Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular health, and its signature in familial frontotemporal dementia (FTD) remains unknown. The primary aim was to investigate CVR in genetic FTD using an fMRI index of vascular contractility termed resting-state fluctuation amplitudes (RSFAs) and to assess whether RSFA differences are moderated by age. A secondary aim was to study the relationship between RSFA and cognition.Participants included presymptomatic and symptomatic C9orf72, GRN, and MAPT pathogenic variation carriers, along with noncarriers, from the prospective Genetic FTD Initiative cohort study. Cross-sectional differences in CVR were assessed using both component-based and voxel-level RSFA maps. To study disease progression-related effects, the moderating effect of age on differences between genetic status groups was analyzed using generalized linear models. The influence of RSFA, and its interaction with genetic status, on participants' cognitive function was also examined. All models were adjusted for sex, handedness, and scanning site and false discovery rate-corrected at p < 0.05.A total of 284 presymptomatic and 124 symptomatic sequence variation carriers, and 265 noncarriers, were included in the analysis (mean age 48.17 years, 55
%K Humans
%K Male
%K Female
%K Frontotemporal Dementia: genetics
%K Frontotemporal Dementia: physiopathology
%K Frontotemporal Dementia: diagnostic imaging
%K Frontotemporal Dementia: psychology
%K Middle Aged
%K Magnetic Resonance Imaging
%K Cognition: physiology
%K Aged
%K C9orf72 Protein: genetics
%K Cross-Sectional Studies
%K tau Proteins: genetics
%K Cerebrovascular Circulation: physiology
%K Progranulins: genetics
%K Adult
%K Brain: diagnostic imaging
%K Brain: physiopathology
%K Brain: blood supply
%K Rest
%K C9orf72 Protein (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%K MAPT protein, human (NLM Chemicals)
%K C9orf72 protein, human (NLM Chemicals)
%K Progranulins (NLM Chemicals)
%K GRN protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40906975
%R 10.1212/WNL.0000000000213677
%U https://pub.dzne.de/record/281113