TY  - JOUR
AU  - Kancheva, Ivana Kirilova
AU  - Bouzigues, Arabella
AU  - Russell, Lucy Louise
AU  - Foster, Phoebe H
AU  - Ferry-Bolder, Eve
AU  - Van Swieten, John C
AU  - Jiskoot, Lize Corrine
AU  - Seelaar, Harro
AU  - Sánchez-Valle, Raquel
AU  - Laforce, Robert
AU  - Graff, Caroline
AU  - Galimberti, Daniela
AU  - Vandenberghe, Rik
AU  - de Mendonça, Alexandre
AU  - Tiraboschi, Pietro
AU  - Santana, Isabel
AU  - Gerhard, Alexander
AU  - Levin, Johannes
AU  - Sorbi, Sandro
AU  - Otto, Markus
AU  - Ducharme, Simon
AU  - Butler, Christopher
AU  - Le Ber, Isabelle
AU  - Finger, Elizabeth
AU  - Tartaglia, Maria Carmela
AU  - Masellis, Mario
AU  - Synofzik, Matthis
AU  - Moreno, Fermin
AU  - Borroni, Barbara
AU  - Rohrer, Jonathan Daniel
AU  - van der Weerd, Louise
AU  - Rowe, James B
AU  - Tsvetanov, Kamen
TI  - Cerebrovascular Reactivity at Rest and Its Association With Cognitive Function in People With Genetic Frontotemporal Dementia.
JO  - Neurology
VL  - 105
IS  - 6
SN  - 0028-3878
CY  - Philadelphia, Pa.
PB  - Wolters Kluwer
M1  - DZNE-2025-01074
SP  - e213677
PY  - 2025
AB  - Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular health, and its signature in familial frontotemporal dementia (FTD) remains unknown. The primary aim was to investigate CVR in genetic FTD using an fMRI index of vascular contractility termed resting-state fluctuation amplitudes (RSFAs) and to assess whether RSFA differences are moderated by age. A secondary aim was to study the relationship between RSFA and cognition.Participants included presymptomatic and symptomatic C9orf72, GRN, and MAPT pathogenic variation carriers, along with noncarriers, from the prospective Genetic FTD Initiative cohort study. Cross-sectional differences in CVR were assessed using both component-based and voxel-level RSFA maps. To study disease progression-related effects, the moderating effect of age on differences between genetic status groups was analyzed using generalized linear models. The influence of RSFA, and its interaction with genetic status, on participants' cognitive function was also examined. All models were adjusted for sex, handedness, and scanning site and false discovery rate-corrected at p < 0.05.A total of 284 presymptomatic and 124 symptomatic sequence variation carriers, and 265 noncarriers, were included in the analysis (mean age 48.17 years, 55
KW  - Humans
KW  - Male
KW  - Female
KW  - Frontotemporal Dementia: genetics
KW  - Frontotemporal Dementia: physiopathology
KW  - Frontotemporal Dementia: diagnostic imaging
KW  - Frontotemporal Dementia: psychology
KW  - Middle Aged
KW  - Magnetic Resonance Imaging
KW  - Cognition: physiology
KW  - Aged
KW  - C9orf72 Protein: genetics
KW  - Cross-Sectional Studies
KW  - tau Proteins: genetics
KW  - Cerebrovascular Circulation: physiology
KW  - Progranulins: genetics
KW  - Adult
KW  - Brain: diagnostic imaging
KW  - Brain: physiopathology
KW  - Brain: blood supply
KW  - Rest
KW  - C9orf72 Protein (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
KW  - MAPT protein, human (NLM Chemicals)
KW  - C9orf72 protein, human (NLM Chemicals)
KW  - Progranulins (NLM Chemicals)
KW  - GRN protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40906975
DO  - DOI:10.1212/WNL.0000000000213677
UR  - https://pub.dzne.de/record/281113
ER  -