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@ARTICLE{Krtvelyessy:281123,
      author       = {Körtvelyessy, Peter and Arslan, Burak and Nietiet, Jonah
                      and Leithner, Christoph and Hühnchen, Petra and Böhmerle,
                      Wolfgang and Endres, Matthias and Ploner, Christoph J and
                      Audebert, Heiner and Hahn, Katrin and Meyer, Thomas and
                      Lüschow, Andreas and Weiss, Claudia and Biztan,
                      Lisa-Valerie and Spethmann, Sebastian and Graw, Adriaan J
                      and Unterwalder, Nadine and Meisel, Christian and Ashton,
                      Nicholas J and Blennow, Kaj and Zetterberg, Henrik and
                      Göschel, Laura},
      title        = {{T}he expanding clinical utility of blood neurofilament
                      light chain (b{N}f{L}): a multi-disciplinary diagnostic
                      tool.},
      journal      = {Journal of the neurological sciences},
      volume       = {478},
      issn         = {0022-510X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2025-01082},
      pages        = {123669},
      year         = {2025},
      abstract     = {The protein neurofilament light chain in blood (bNfL) has
                      become a valuable biomarker in the diagnosis, monitoring,
                      and prognosis of neurological diseases. However, its
                      potential use beyond neurology in routine clinical practice
                      remains unexplored. This study aimed to examine the clinical
                      utility of bNfL by investigating its expanding use (i)
                      assessing its integration into in- and outpatient routine
                      practice, (ii) both within and outside of academic
                      hospitals, and (iii) across different medical disciplines
                      and various departments.This study examined data from two
                      large clinical chemistry laboratories that provide bNfL
                      measurements for the clinical routine: Labor Berlin,
                      Germany, and the Clinical Neurochemistry Laboratory at
                      Sahlgrenska University Hospital, Sweden. Together, this
                      large-scale retrospective study acquired data on bNfL
                      measurements from n = 22,122 individuals during the years
                      2021 to 2023.Our findings revealed that (i) outpatient
                      clinics and (ii) non-academic healthcare settings are
                      gradually integrating bNfL into their routine practice and
                      (iii) its use has expanded across an increasing number of
                      medical disciplines over time, indicating its growing
                      importance as a diagnostic tool, beyond neurology. Notably,
                      departments such as cardiology, hematology/oncology and
                      intensive care units increasingly incorporated bNfL into
                      their clinical repertoire.This study underscores the
                      developing impact of easily accessible bNfL on clinical
                      routine, not only enhancing neurologists' diagnostic tools
                      but also offering valuable insights into diverse medical
                      fields, in- and outside the academic environment.},
      keywords     = {Neurofilament light chain (Other) / Neurology (Other) /
                      Real world data (Other) / Serum (Other)},
      cin          = {AG Düzel / AG Endres},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006 / I:(DE-2719)1811005},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40912227},
      doi          = {10.1016/j.jns.2025.123669},
      url          = {https://pub.dzne.de/record/281123},
}