%0 Journal Article
%A Yiallourou, Stephanie
%A Baril, Andree-Ann
%A Wiedner, Crystal
%A Misialek, Jeffrey R
%A Kline, Christopher E
%A Harrison, Stephanie
%A Cannon, Ethan
%A Yang, Qiong
%A Bernal, Rebecca
%A Bisson, Alycia
%A Himali, Dibya
%A Cavuoto, Marina
%A Weihs, Antoine
%A Beiser, Alexa
%A Gottesman, Rebecca F
%A Leng, Yue
%A Lopez, Oscar
%A Lutsey, Pamela L
%A Purcell, Shaun M
%A Redline, Susan
%A Seshadri, Sudha
%A Stone, Katie L
%A Yaffe, Kristine
%A Ancoli-Israel, Sonia
%A Xiao, Qian
%A Vaou, Eleni Okeanis
%A Himali, Jayandra J
%A Pase, Matthew P
%T Sleep architecture and dementia risk in adults: an analysis of 5 cohorts from the Sleep and Dementia Consortium.
%J Sleep
%V 48
%N 9
%@ 0161-8105
%C Oxford
%I Oxford Univ. Press
%M DZNE-2025-01086
%P zsaf129
%D 2025
%X Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. We examined the relationship between sleep architecture and dementia incidence across five US-based cohort studies from the Sleep and Dementia Consortium.Percent of time spent in stages of sleep (N1, N2, N3, rapid eye movement sleep), wake after sleep onset, sleep maintenance efficiency, apnea-hypopnea index, and relative delta power were derived from a single night home-based PSG. Dementia was ascertained in each cohort using its cohort-specific criteria. Each cohort performed Cox proportional hazard regressions for each sleep exposure and incident dementia, adjusting for age, sex, body mass index, antidepressant use, sedative use, and APOE e4 status. Results were then pooled in a random effects model.The pooled sample comprised 4657 participants (30
%K Humans
%K Dementia: epidemiology
%K Female
%K Male
%K Aged
%K Polysomnography
%K Middle Aged
%K Cohort Studies
%K Risk Factors
%K Incidence
%K Sleep: physiology
%K Sleep Stages: physiology
%K United States: epidemiology
%K Alzheimer’s disease (Other)
%K dementia (Other)
%K sleep (Other)
%K sleep macro-architecture (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40377976
%2 pmc:PMC12417016
%R 10.1093/sleep/zsaf129
%U https://pub.dzne.de/record/281127