TY  - JOUR
AU  - Yiallourou, Stephanie
AU  - Baril, Andree-Ann
AU  - Wiedner, Crystal
AU  - Misialek, Jeffrey R
AU  - Kline, Christopher E
AU  - Harrison, Stephanie
AU  - Cannon, Ethan
AU  - Yang, Qiong
AU  - Bernal, Rebecca
AU  - Bisson, Alycia
AU  - Himali, Dibya
AU  - Cavuoto, Marina
AU  - Weihs, Antoine
AU  - Beiser, Alexa
AU  - Gottesman, Rebecca F
AU  - Leng, Yue
AU  - Lopez, Oscar
AU  - Lutsey, Pamela L
AU  - Purcell, Shaun M
AU  - Redline, Susan
AU  - Seshadri, Sudha
AU  - Stone, Katie L
AU  - Yaffe, Kristine
AU  - Ancoli-Israel, Sonia
AU  - Xiao, Qian
AU  - Vaou, Eleni Okeanis
AU  - Himali, Jayandra J
AU  - Pase, Matthew P
TI  - Sleep architecture and dementia risk in adults: an analysis of 5 cohorts from the Sleep and Dementia Consortium.
JO  - Sleep
VL  - 48
IS  - 9
SN  - 0161-8105
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DZNE-2025-01086
SP  - zsaf129
PY  - 2025
AB  - Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. We examined the relationship between sleep architecture and dementia incidence across five US-based cohort studies from the Sleep and Dementia Consortium.Percent of time spent in stages of sleep (N1, N2, N3, rapid eye movement sleep), wake after sleep onset, sleep maintenance efficiency, apnea-hypopnea index, and relative delta power were derived from a single night home-based PSG. Dementia was ascertained in each cohort using its cohort-specific criteria. Each cohort performed Cox proportional hazard regressions for each sleep exposure and incident dementia, adjusting for age, sex, body mass index, antidepressant use, sedative use, and APOE e4 status. Results were then pooled in a random effects model.The pooled sample comprised 4657 participants (30
KW  - Humans
KW  - Dementia: epidemiology
KW  - Female
KW  - Male
KW  - Aged
KW  - Polysomnography
KW  - Middle Aged
KW  - Cohort Studies
KW  - Risk Factors
KW  - Incidence
KW  - Sleep: physiology
KW  - Sleep Stages: physiology
KW  - United States: epidemiology
KW  - Alzheimer’s disease (Other)
KW  - dementia (Other)
KW  - sleep (Other)
KW  - sleep macro-architecture (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40377976
C2  - pmc:PMC12417016
DO  - DOI:10.1093/sleep/zsaf129
UR  - https://pub.dzne.de/record/281127
ER  -