%0 Journal Article
%A Kherbouche, Oussama
%A Henning, Lukas
%A Niemann, Pia
%A Geisen, Caroline
%A Seifert, Gerald
%A Henneberger, Christian
%A Fleischmann, Bernd K
%A Steinhäuser, Christian
%A Bedner, Peter
%T Induced Overexpression of Connexin43 in Astrocytes Attenuates the Progression of Experimental Temporal Lobe Epilepsy.
%J Neurochemical research
%V 50
%N 5
%@ 0364-3190
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V
%M DZNE-2025-01093
%P 303
%D 2025
%X Astrocytic gap junctional communication plays a critical role in regulating neuronal activity and network synchronization, yet its precise contributions to brain function and the pathogenesis of neurological disorders remains incompletely understood. To address this, we generated a transgenic mouse line with inducible, astrocyte-specific overexpression of the gap junction protein connexin43 (Cx43). In these mice, hippocampal astrocytes exhibited markedly elevated Cx43 protein levels and a   20
%K Animals
%K Astrocytes: metabolism
%K Connexin 43: biosynthesis
%K Connexin 43: genetics
%K Epilepsy, Temporal Lobe: metabolism
%K Epilepsy, Temporal Lobe: pathology
%K Mice, Transgenic
%K Mice
%K Disease Progression
%K Hippocampus: metabolism
%K Hippocampus: pathology
%K Mice, Inbred C57BL
%K Gap Junctions: metabolism
%K Male
%K Connexin 43 (Other)
%K EEG (Other)
%K Electrophysiology (Other)
%K Gap junction coupling (Other)
%K Hippocampal sclerosis (Other)
%K Temporal lobe epilepsy (Other)
%K Connexin 43 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40965686
%2 pmc:PMC12446404
%R 10.1007/s11064-025-04558-w
%U https://pub.dzne.de/record/281346