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000281346 037__ $$aDZNE-2025-01093
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000281346 1001_ $$aKherbouche, Oussama$$b0
000281346 245__ $$aInduced Overexpression of Connexin43 in Astrocytes Attenuates the Progression of Experimental Temporal Lobe Epilepsy.
000281346 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V$$c2025
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000281346 520__ $$aAstrocytic gap junctional communication plays a critical role in regulating neuronal activity and network synchronization, yet its precise contributions to brain function and the pathogenesis of neurological disorders remains incompletely understood. To address this, we generated a transgenic mouse line with inducible, astrocyte-specific overexpression of the gap junction protein connexin43 (Cx43). In these mice, hippocampal astrocytes exhibited markedly elevated Cx43 protein levels and a ~ 20% increase in intercellular gap junction coupling. Enhanced coupling was accompanied by a reduction in astrocytic cell volume and branching, without affecting passive membrane properties or astrocyte density in the hippocampus. Cx43 overexpression had no detectable impact on adult neurogenesis in the dentate gyrus, nor did it alter hippocampal synaptic efficacy or plasticity. Notably, in a mouse model of temporal lobe epilepsy with hippocampal sclerosis, astrocytic Cx43 overexpression attenuated chronic epileptic activity and the extent of sclerosis, supporting an antiepileptic role of the astroglial network. Collectively, these findings enhance our understanding of the functional relevance of astrocytic gap junction coupling in health and disease, with potential implications for the design of new treatment strategies.
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000281346 650_7 $$2Other$$aConnexin 43
000281346 650_7 $$2Other$$aEEG
000281346 650_7 $$2Other$$aElectrophysiology
000281346 650_7 $$2Other$$aGap junction coupling
000281346 650_7 $$2Other$$aHippocampal sclerosis
000281346 650_7 $$2Other$$aTemporal lobe epilepsy
000281346 650_7 $$2NLM Chemicals$$aConnexin 43
000281346 650_2 $$2MeSH$$aAnimals
000281346 650_2 $$2MeSH$$aAstrocytes: metabolism
000281346 650_2 $$2MeSH$$aConnexin 43: biosynthesis
000281346 650_2 $$2MeSH$$aConnexin 43: genetics
000281346 650_2 $$2MeSH$$aEpilepsy, Temporal Lobe: metabolism
000281346 650_2 $$2MeSH$$aEpilepsy, Temporal Lobe: pathology
000281346 650_2 $$2MeSH$$aMice, Transgenic
000281346 650_2 $$2MeSH$$aMice
000281346 650_2 $$2MeSH$$aDisease Progression
000281346 650_2 $$2MeSH$$aHippocampus: metabolism
000281346 650_2 $$2MeSH$$aHippocampus: pathology
000281346 650_2 $$2MeSH$$aMice, Inbred C57BL
000281346 650_2 $$2MeSH$$aGap Junctions: metabolism
000281346 650_2 $$2MeSH$$aMale
000281346 7001_ $$aHenning, Lukas$$b1
000281346 7001_ $$aNiemann, Pia$$b2
000281346 7001_ $$aGeisen, Caroline$$b3
000281346 7001_ $$aSeifert, Gerald$$b4
000281346 7001_ $$0P:(DE-2719)2811625$$aHenneberger, Christian$$b5$$udzne
000281346 7001_ $$aFleischmann, Bernd K$$b6
000281346 7001_ $$00000-0003-2579-8357$$aSteinhäuser, Christian$$b7
000281346 7001_ $$00000-0003-0090-7553$$aBedner, Peter$$b8
000281346 773__ $$0PERI:(DE-600)2018503-0$$a10.1007/s11064-025-04558-w$$gVol. 50, no. 5, p. 303$$n5$$p303$$tNeurochemical research$$v50$$x0364-3190$$y2025
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