TY  - JOUR
AU  - Kherbouche, Oussama
AU  - Henning, Lukas
AU  - Niemann, Pia
AU  - Geisen, Caroline
AU  - Seifert, Gerald
AU  - Henneberger, Christian
AU  - Fleischmann, Bernd K
AU  - Steinhäuser, Christian
AU  - Bedner, Peter
TI  - Induced Overexpression of Connexin43 in Astrocytes Attenuates the Progression of Experimental Temporal Lobe Epilepsy.
JO  - Neurochemical research
VL  - 50
IS  - 5
SN  - 0364-3190
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - DZNE-2025-01093
SP  - 303
PY  - 2025
AB  - Astrocytic gap junctional communication plays a critical role in regulating neuronal activity and network synchronization, yet its precise contributions to brain function and the pathogenesis of neurological disorders remains incompletely understood. To address this, we generated a transgenic mouse line with inducible, astrocyte-specific overexpression of the gap junction protein connexin43 (Cx43). In these mice, hippocampal astrocytes exhibited markedly elevated Cx43 protein levels and a   20
KW  - Animals
KW  - Astrocytes: metabolism
KW  - Connexin 43: biosynthesis
KW  - Connexin 43: genetics
KW  - Epilepsy, Temporal Lobe: metabolism
KW  - Epilepsy, Temporal Lobe: pathology
KW  - Mice, Transgenic
KW  - Mice
KW  - Disease Progression
KW  - Hippocampus: metabolism
KW  - Hippocampus: pathology
KW  - Mice, Inbred C57BL
KW  - Gap Junctions: metabolism
KW  - Male
KW  - Connexin 43 (Other)
KW  - EEG (Other)
KW  - Electrophysiology (Other)
KW  - Gap junction coupling (Other)
KW  - Hippocampal sclerosis (Other)
KW  - Temporal lobe epilepsy (Other)
KW  - Connexin 43 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40965686
C2  - pmc:PMC12446404
DO  - DOI:10.1007/s11064-025-04558-w
UR  - https://pub.dzne.de/record/281346
ER  -