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@ARTICLE{Cordonnier:281348,
author = {Cordonnier, Charlotte and Klijn, Catharina and Smith, Eric
Edward and Al-Shahi Salman, Rustam and Chwalisz, Bart K and
van Etten, Ellis and Muir, Ryan T and Piazza, Fabrizio and
Schreiber, Stefanie and Schreuder, Floris Hbm and Selim,
Magdy and Shoamanesh, Ashkan and Viswanathan, Anand and
Wermer, Marieke and Zandi, Michael and Charidimou, Andreas
and Greenberg, Steven M and Werring, David},
title = {{D}iagnosis and management of cerebral amyloid angiopathy:
a scientific statement from the {I}nternational {CAA}
{A}ssociation and the {W}orld {S}troke {O}rganization.},
journal = {International journal of stroke},
volume = {20},
number = {8},
issn = {1747-4930},
address = {London},
publisher = {Sage},
reportid = {DZNE-2025-01095},
pages = {949 - 967},
year = {2025},
abstract = {Cerebral amyloid angiopathy (CAA) is a well-recognized and
challenging disease for neurologists and other clinicians
caring for the rapidly aging worldwide population. CAA is a
major cause of spontaneous lobar intracerebral hemorrhage
(ICH), and can also cause transient focal neurological
episodes, and convexity subarachnoid hemorrhage,
CAA-associated ICH has a high mortality, morbidity, and
recurrence rate. CAA can affect a wide range of clinical
decisions including use of antithrombotic medications,
safety for anti-β-amyloid peptide (Aβ) immunotherapy, and
need for anti-inflammatory or immunosuppressive treatment.
We present guidelines, intended to inform the approach to
individuals with suspected CAA, written on behalf of the
International CAA Association and the World Stroke
Organization (WSO). We cover five areas selected for their
relevance to practice: (1) diagnosis, testing, and
prediction of intracerebral hemorrhage risk; (2)
antithrombotic agents and vascular interventions; (3)
vascular risk factors and concomitant medications; (4)
treatment of CAA manifestations; and (5) diagnosis and
treatment of CAA-related inflammation and vasculitis. The
statement has been reviewed and approved by the Executive
Committee of the WSO, and the International CAA
Association.},
subtyp = {Review Article},
keywords = {Humans / Cerebral Amyloid Angiopathy: diagnosis / Cerebral
Amyloid Angiopathy: therapy / Cerebral Amyloid Angiopathy:
complications / Disease Management / Cerebral Hemorrhage:
etiology / Cerebral Hemorrhage: therapy / Cerebral
Hemorrhage: diagnosis / Stroke: therapy / Stroke: diagnosis
/ Risk Factors / Fibrinolytic Agents: therapeutic use /
Societies, Medical / MRI (Other) / antithrombotic (Other) /
brain bleed (Other) / brain microbleeds (Other) / cerebral
hemorrhage (Other) / leukoaraiosis (Other) / Fibrinolytic
Agents (NLM Chemicals)},
cin = {AG Schreiber},
ddc = {610},
cid = {I:(DE-2719)1310010},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:40721902},
doi = {10.1177/17474930251365861},
url = {https://pub.dzne.de/record/281348},
}