%0 Journal Article
%A Rodrigues, Mark A
%A Seiffge, David
%A Samarasekera, Neshika
%A Moullaali, Tom J
%A Wardlaw, Joanna M
%A Schreiber, Stefanie
%A Behymer, Tyler P
%A Khandwala, Vivek
%A Stanton, Robert J
%A Vagal, Vaibhav
%A Woo, Daniel
%A Zedde, Marialuisa
%A Pascarella, Rosario
%A Charidimou, Andreas
%A Warren, Andrew
%A Greenberg, Steven M
%A Eppinger, Sebastian
%A Gattringer, Thomas
%A Casolla, Barbara
%A Cordonnier, Charlotte
%A Werring, David J
%A Al-Shahi Salman, Rustam
%T Association between the Edinburgh CT and genetic diagnostic criteria for cerebral amyloid angiopathy-associated lobar intracerebral haemorrhage and recurrent intracerebral haemorrhage: an individual patient data meta-analysis.
%J The lancet
%V 24
%N 10
%@ 1474-4422
%C London
%I Lancet Publ. Group
%M DZNE-2025-01097
%P 828 - 839
%D 2025
%X Patients with lobar intracerebral haemorrhage and MRI biomarkers of cerebral amyloid angiopathy have a greater risk of recurrent intracerebral haemorrhage than patients without these biomarkers. However, access to MRI is limited. We aimed to determine whether the Edinburgh CT-only and CT-APOE diagnostic criteria for cerebral amyloid angiopathy-related lobar intracerebral haemorrhage are associated with recurrent intracerebral haemorrhage.We did a meta-analysis of individual patient data from cohort studies identified at the 2018 International cerebral amyloid angiopathy conference in Lille, France, assessing patients with lobar intracerebral haemorrhage with available diagnostic CT imaging that had been, or could be, rated for the Edinburgh cerebral amyloid angiopathy criteria imaging features, and with follow-up data for recurrent intracerebral haemorrhage and death. Eligible patients were aged 16 years or older with first or recurrent spontaneous lobar intracerebral haemorrhage diagnosed by non-contrast brain CT, with no evidence of an underlying cause other than cerebral small vessel disease. Collaborators provided individual patient-level data. The primary outcome was first recurrent intracerebral haemorrhage occurring at least 30 days after the index event, analysed using primary two-stage (cohort-level) and secondary one-stage (pooled) meta-analyses with multivariable regression models with a competing risk of death, adjusted for age, sex, and CT small vessel disease score. Pooled analyses were adjusted for previous intracerebral haemorrhage, dementia, hypertension, and cohort clustering. All analyses were done in R Project for Statistical Computing (version 4.5.0).We included eight cohorts from Austria, France, Germany, Italy, the UK, and the USA, with 1705 eligible patients for the CT-only criteria. In the primary two-stage meta-analysis of the CT-only criteria (562 patients from three European cohorts, median age 76 years [IQR 68-82], 282 [50
%K Humans
%K Cerebral Amyloid Angiopathy: genetics
%K Cerebral Amyloid Angiopathy: diagnostic imaging
%K Cerebral Amyloid Angiopathy: complications
%K Cerebral Amyloid Angiopathy: diagnosis
%K Cerebral Hemorrhage: diagnostic imaging
%K Cerebral Hemorrhage: genetics
%K Cerebral Hemorrhage: etiology
%K Recurrence
%K Male
%K Female
%K Tomography, X-Ray Computed
%K Aged
%K Middle Aged
%K Cohort Studies
%K Aged, 80 and over
%K Apolipoproteins E: genetics
%K Apolipoproteins E (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40975099
%R 10.1016/S1474-4422(25)00285-6
%U https://pub.dzne.de/record/281350