TY  - JOUR
AU  - Rodrigues, Mark A
AU  - Seiffge, David
AU  - Samarasekera, Neshika
AU  - Moullaali, Tom J
AU  - Wardlaw, Joanna M
AU  - Schreiber, Stefanie
AU  - Behymer, Tyler P
AU  - Khandwala, Vivek
AU  - Stanton, Robert J
AU  - Vagal, Vaibhav
AU  - Woo, Daniel
AU  - Zedde, Marialuisa
AU  - Pascarella, Rosario
AU  - Charidimou, Andreas
AU  - Warren, Andrew
AU  - Greenberg, Steven M
AU  - Eppinger, Sebastian
AU  - Gattringer, Thomas
AU  - Casolla, Barbara
AU  - Cordonnier, Charlotte
AU  - Werring, David J
AU  - Al-Shahi Salman, Rustam
TI  - Association between the Edinburgh CT and genetic diagnostic criteria for cerebral amyloid angiopathy-associated lobar intracerebral haemorrhage and recurrent intracerebral haemorrhage: an individual patient data meta-analysis.
JO  - The lancet
VL  - 24
IS  - 10
SN  - 1474-4422
CY  - London
PB  - Lancet Publ. Group
M1  - DZNE-2025-01097
SP  - 828 - 839
PY  - 2025
AB  - Patients with lobar intracerebral haemorrhage and MRI biomarkers of cerebral amyloid angiopathy have a greater risk of recurrent intracerebral haemorrhage than patients without these biomarkers. However, access to MRI is limited. We aimed to determine whether the Edinburgh CT-only and CT-APOE diagnostic criteria for cerebral amyloid angiopathy-related lobar intracerebral haemorrhage are associated with recurrent intracerebral haemorrhage.We did a meta-analysis of individual patient data from cohort studies identified at the 2018 International cerebral amyloid angiopathy conference in Lille, France, assessing patients with lobar intracerebral haemorrhage with available diagnostic CT imaging that had been, or could be, rated for the Edinburgh cerebral amyloid angiopathy criteria imaging features, and with follow-up data for recurrent intracerebral haemorrhage and death. Eligible patients were aged 16 years or older with first or recurrent spontaneous lobar intracerebral haemorrhage diagnosed by non-contrast brain CT, with no evidence of an underlying cause other than cerebral small vessel disease. Collaborators provided individual patient-level data. The primary outcome was first recurrent intracerebral haemorrhage occurring at least 30 days after the index event, analysed using primary two-stage (cohort-level) and secondary one-stage (pooled) meta-analyses with multivariable regression models with a competing risk of death, adjusted for age, sex, and CT small vessel disease score. Pooled analyses were adjusted for previous intracerebral haemorrhage, dementia, hypertension, and cohort clustering. All analyses were done in R Project for Statistical Computing (version 4.5.0).We included eight cohorts from Austria, France, Germany, Italy, the UK, and the USA, with 1705 eligible patients for the CT-only criteria. In the primary two-stage meta-analysis of the CT-only criteria (562 patients from three European cohorts, median age 76 years [IQR 68-82], 282 [50
KW  - Humans
KW  - Cerebral Amyloid Angiopathy: genetics
KW  - Cerebral Amyloid Angiopathy: diagnostic imaging
KW  - Cerebral Amyloid Angiopathy: complications
KW  - Cerebral Amyloid Angiopathy: diagnosis
KW  - Cerebral Hemorrhage: diagnostic imaging
KW  - Cerebral Hemorrhage: genetics
KW  - Cerebral Hemorrhage: etiology
KW  - Recurrence
KW  - Male
KW  - Female
KW  - Tomography, X-Ray Computed
KW  - Aged
KW  - Middle Aged
KW  - Cohort Studies
KW  - Aged, 80 and over
KW  - Apolipoproteins E: genetics
KW  - Apolipoproteins E (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40975099
DO  - DOI:10.1016/S1474-4422(25)00285-6
UR  - https://pub.dzne.de/record/281350
ER  -