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000281353 0247_ $$2doi$$a10.1016/j.neuron.2025.06.016
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000281353 041__ $$aEnglish
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000281353 1001_ $$aDitzer, Nora$$b0
000281353 245__ $$aEpigenome profiling identifies H3K27me3 regulation of extracellular matrix composition in human corticogenesis.
000281353 260__ $$a[Cambridge, Mass.]$$bCell Press$$c2025
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000281353 520__ $$aEpigenetic mechanisms regulate gene expression programs during neurogenesis, but the extent of epigenetic remodeling during human cortical development remains unknown. Here, we characterize the epigenetic landscape of the human developing neocortex by leveraging Epi-CyTOF, a mass-cytometry-based approach for the simultaneous single-cell analysis of more than 30 epigenetic marks. We identify Polycomb repressive complex 2 (PRC2)-mediated H3K27me3 as the modification with the strongest cell-type-specific enrichment. Inhibition of PRC2 in human cortical organoids resulted in a shift of neural progenitor cell (NPC) proliferation toward differentiation. Cell-type-specific profiling of H3K27me3 identified neuronal differentiation and extracellular matrix (ECM) genes in the human neocortex. PRC2 inhibition resulted in increased production of the ECM proteins Syndecan 1 and laminin alpha 1. Overall, this study comprehensively characterizes the epigenetic state of specific neural cell types and highlights a novel role for H3K27me3 in regulating the ECM composition in the human developing neocortex.
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000281353 650_7 $$2Other$$aPolycomb repressive complex 2
000281353 650_7 $$2Other$$abrain development
000281353 650_7 $$2Other$$aextracellular matrix
000281353 650_7 $$2Other$$agene expression
000281353 650_7 $$2Other$$ahistone methylation
000281353 650_7 $$2Other$$ahuman cortical organoid
000281353 650_7 $$2Other$$ahuman fetal cortex
000281353 650_7 $$2Other$$aneural stem cell
000281353 650_7 $$2Other$$aneurogenesis
000281353 650_7 $$2Other$$asingle cell
000281353 650_7 $$2NLM Chemicals$$aHistones
000281353 650_7 $$0EC 2.1.1.43$$2NLM Chemicals$$aPolycomb Repressive Complex 2
000281353 650_2 $$2MeSH$$aHumans
000281353 650_2 $$2MeSH$$aExtracellular Matrix: metabolism
000281353 650_2 $$2MeSH$$aExtracellular Matrix: genetics
000281353 650_2 $$2MeSH$$aHistones: metabolism
000281353 650_2 $$2MeSH$$aHistones: genetics
000281353 650_2 $$2MeSH$$aNeurogenesis: physiology
000281353 650_2 $$2MeSH$$aNeurogenesis: genetics
000281353 650_2 $$2MeSH$$aNeocortex: metabolism
000281353 650_2 $$2MeSH$$aNeocortex: growth & development
000281353 650_2 $$2MeSH$$aNeural Stem Cells: metabolism
000281353 650_2 $$2MeSH$$aEpigenome
000281353 650_2 $$2MeSH$$aPolycomb Repressive Complex 2: metabolism
000281353 650_2 $$2MeSH$$aPolycomb Repressive Complex 2: genetics
000281353 650_2 $$2MeSH$$aEpigenesis, Genetic
000281353 650_2 $$2MeSH$$aCell Differentiation
000281353 7001_ $$aSenoglu, Ezgi$$b1
000281353 7001_ $$aKolodziejczyk, Annika$$b2
000281353 7001_ $$aSchütze, Theresa M$$b3
000281353 7001_ $$aNikolaidi, Aikaterina$$b4
000281353 7001_ $$aKüster, Karolin$$b5
000281353 7001_ $$aSameith, Katrin$$b6
000281353 7001_ $$aDietz, Sevina$$b7
000281353 7001_ $$aDerihaci, Razvan P$$b8
000281353 7001_ $$aBirdir, Cahit$$b9
000281353 7001_ $$aEugster, Anne$$b10
000281353 7001_ $$0P:(DE-2719)2000041$$aKarl, Mike O$$b11$$udzne
000281353 7001_ $$aDahl, Andreas$$b12
000281353 7001_ $$aWimberger, Pauline$$b13
000281353 7001_ $$aBaenke, Franziska$$b14
000281353 7001_ $$aPeitzsch, Claudia$$b15
000281353 7001_ $$aAlbert, Mareike$$b16
000281353 773__ $$0PERI:(DE-600)2001944-0$$a10.1016/j.neuron.2025.06.016$$gVol. 113, no. 18, p. 2927 - 2944.e10$$n18$$p2927 - 2944.e10$$tNeuron$$v113$$x0896-6273$$y2025
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