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@ARTICLE{Ditzer:281353,
      author       = {Ditzer, Nora and Senoglu, Ezgi and Kolodziejczyk, Annika
                      and Schütze, Theresa M and Nikolaidi, Aikaterina and
                      Küster, Karolin and Sameith, Katrin and Dietz, Sevina and
                      Derihaci, Razvan P and Birdir, Cahit and Eugster, Anne and
                      Karl, Mike O and Dahl, Andreas and Wimberger, Pauline and
                      Baenke, Franziska and Peitzsch, Claudia and Albert, Mareike},
      title        = {{E}pigenome profiling identifies {H}3{K}27me3 regulation of
                      extracellular matrix composition in human corticogenesis.},
      journal      = {Neuron},
      volume       = {113},
      number       = {18},
      issn         = {0896-6273},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {DZNE-2025-01100},
      pages        = {2927 - 2944.e10},
      year         = {2025},
      abstract     = {Epigenetic mechanisms regulate gene expression programs
                      during neurogenesis, but the extent of epigenetic remodeling
                      during human cortical development remains unknown. Here, we
                      characterize the epigenetic landscape of the human
                      developing neocortex by leveraging Epi-CyTOF, a
                      mass-cytometry-based approach for the simultaneous
                      single-cell analysis of more than 30 epigenetic marks. We
                      identify Polycomb repressive complex 2 (PRC2)-mediated
                      H3K27me3 as the modification with the strongest
                      cell-type-specific enrichment. Inhibition of PRC2 in human
                      cortical organoids resulted in a shift of neural progenitor
                      cell (NPC) proliferation toward differentiation.
                      Cell-type-specific profiling of H3K27me3 identified neuronal
                      differentiation and extracellular matrix (ECM) genes in the
                      human neocortex. PRC2 inhibition resulted in increased
                      production of the ECM proteins Syndecan 1 and laminin alpha
                      1. Overall, this study comprehensively characterizes the
                      epigenetic state of specific neural cell types and
                      highlights a novel role for H3K27me3 in regulating the ECM
                      composition in the human developing neocortex.},
      keywords     = {Humans / Extracellular Matrix: metabolism / Extracellular
                      Matrix: genetics / Histones: metabolism / Histones: genetics
                      / Neurogenesis: physiology / Neurogenesis: genetics /
                      Neocortex: metabolism / Neocortex: growth $\&$ development /
                      Neural Stem Cells: metabolism / Epigenome / Polycomb
                      Repressive Complex 2: metabolism / Polycomb Repressive
                      Complex 2: genetics / Epigenesis, Genetic / Cell
                      Differentiation / Polycomb repressive complex 2 (Other) /
                      brain development (Other) / extracellular matrix (Other) /
                      gene expression (Other) / histone methylation (Other) /
                      human cortical organoid (Other) / human fetal cortex (Other)
                      / neural stem cell (Other) / neurogenesis (Other) / single
                      cell (Other) / Histones (NLM Chemicals) / Polycomb
                      Repressive Complex 2 (NLM Chemicals)},
      cin          = {AG Karl},
      ddc          = {610},
      cid          = {I:(DE-2719)1710004},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40701154},
      doi          = {10.1016/j.neuron.2025.06.016},
      url          = {https://pub.dzne.de/record/281353},
}