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001     281353
005     20251112102900.0
024 7 _ |a 10.1016/j.neuron.2025.06.016
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024 7 _ |a 0896-6273
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024 7 _ |a 1097-4199
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037 _ _ |a DZNE-2025-01100
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Ditzer, Nora
|b 0
245 _ _ |a Epigenome profiling identifies H3K27me3 regulation of extracellular matrix composition in human corticogenesis.
260 _ _ |a [Cambridge, Mass.]
|c 2025
|b Cell Press
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336 7 _ |a ARTICLE
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520 _ _ |a Epigenetic mechanisms regulate gene expression programs during neurogenesis, but the extent of epigenetic remodeling during human cortical development remains unknown. Here, we characterize the epigenetic landscape of the human developing neocortex by leveraging Epi-CyTOF, a mass-cytometry-based approach for the simultaneous single-cell analysis of more than 30 epigenetic marks. We identify Polycomb repressive complex 2 (PRC2)-mediated H3K27me3 as the modification with the strongest cell-type-specific enrichment. Inhibition of PRC2 in human cortical organoids resulted in a shift of neural progenitor cell (NPC) proliferation toward differentiation. Cell-type-specific profiling of H3K27me3 identified neuronal differentiation and extracellular matrix (ECM) genes in the human neocortex. PRC2 inhibition resulted in increased production of the ECM proteins Syndecan 1 and laminin alpha 1. Overall, this study comprehensively characterizes the epigenetic state of specific neural cell types and highlights a novel role for H3K27me3 in regulating the ECM composition in the human developing neocortex.
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650 _ 7 |a Polycomb repressive complex 2
|2 Other
650 _ 7 |a brain development
|2 Other
650 _ 7 |a extracellular matrix
|2 Other
650 _ 7 |a gene expression
|2 Other
650 _ 7 |a histone methylation
|2 Other
650 _ 7 |a human cortical organoid
|2 Other
650 _ 7 |a human fetal cortex
|2 Other
650 _ 7 |a neural stem cell
|2 Other
650 _ 7 |a neurogenesis
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650 _ 7 |a single cell
|2 Other
650 _ 7 |a Histones
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650 _ 7 |a Polycomb Repressive Complex 2
|0 EC 2.1.1.43
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Extracellular Matrix: metabolism
|2 MeSH
650 _ 2 |a Extracellular Matrix: genetics
|2 MeSH
650 _ 2 |a Histones: metabolism
|2 MeSH
650 _ 2 |a Histones: genetics
|2 MeSH
650 _ 2 |a Neurogenesis: physiology
|2 MeSH
650 _ 2 |a Neurogenesis: genetics
|2 MeSH
650 _ 2 |a Neocortex: metabolism
|2 MeSH
650 _ 2 |a Neocortex: growth & development
|2 MeSH
650 _ 2 |a Neural Stem Cells: metabolism
|2 MeSH
650 _ 2 |a Epigenome
|2 MeSH
650 _ 2 |a Polycomb Repressive Complex 2: metabolism
|2 MeSH
650 _ 2 |a Polycomb Repressive Complex 2: genetics
|2 MeSH
650 _ 2 |a Epigenesis, Genetic
|2 MeSH
650 _ 2 |a Cell Differentiation
|2 MeSH
700 1 _ |a Senoglu, Ezgi
|b 1
700 1 _ |a Kolodziejczyk, Annika
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700 1 _ |a Schütze, Theresa M
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700 1 _ |a Nikolaidi, Aikaterina
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700 1 _ |a Küster, Karolin
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700 1 _ |a Sameith, Katrin
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700 1 _ |a Dietz, Sevina
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700 1 _ |a Derihaci, Razvan P
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700 1 _ |a Birdir, Cahit
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700 1 _ |a Eugster, Anne
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700 1 _ |a Karl, Mike O
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700 1 _ |a Dahl, Andreas
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700 1 _ |a Wimberger, Pauline
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700 1 _ |a Baenke, Franziska
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700 1 _ |a Peitzsch, Claudia
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700 1 _ |a Albert, Mareike
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773 _ _ |a 10.1016/j.neuron.2025.06.016
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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