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@ARTICLE{Drwesh:281356,
      author       = {Drwesh, Layla and Arena, Giuseppe and Merk, Daniel J and
                      Ferrante, Daniele and Gorgogietas, Vyron and Gasser, Thomas
                      and Grünewald, Anne and May, Patrick and Brockmann, Kathrin
                      and Krüger, Rejko and Wüst, Richard and Gloeckner,
                      Christian Johannes and Fitzgerald, Julia C},
      title        = {{M}ethodological validation of {M}iro1 retention as a
                      candidate {P}arkinson's disease biomarker.},
      journal      = {npj Parkinson's Disease},
      volume       = {11},
      number       = {1},
      issn         = {2373-8057},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-01103},
      pages        = {270},
      year         = {2025},
      abstract     = {Mitochondrial markers help stratify Parkinson's disease
                      (PD) patients. We use high-throughput blotting to quantify
                      Miro1, Mfn2, and VDAC levels in fibroblasts, blood cells,
                      and iPSC-derived neurons. Miro1 is specifically retained in
                      PD cells but degraded in healthy ones after mitochondrial
                      depolarization. We correlate Miro1 retention scores with
                      pathogenic mutations, genetic background, age, and clinical
                      data. This scalable assay and quantifiable score for
                      mitochondrial-PD support biomarker development and
                      pharmacological screening.},
      cin          = {AG Gasser / AG Gloeckner},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000 / I:(DE-2719)1210007},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40954161},
      pmc          = {pmc:PMC12436598},
      doi          = {10.1038/s41531-025-01115-8},
      url          = {https://pub.dzne.de/record/281356},
}