TY  - JOUR
AU  - Coors, Annabell
AU  - Zeng, Weiyi
AU  - Ettinger, Ulrich
AU  - Breteler, Monique M B
TI  - Neuropathology determines whether brain systems segregation benefits cognitive performance.
JO  - Imaging neuroscience
VL  - 3
SN  - 2837-6056
CY  - Cambridge, MA
PB  - MIT Press
M1  - DZNE-2025-01108
SP  - IMAG.a.138
PY  - 2025
AB  - The human brain is a large-scale network, containing multiple segregated, functionally specialized systems. With increasing age, these systems become less segregated, but the reasons and consequences of this age-related reorganization are largely unknown. Thus, after characterizing age- and sex-specific differences in the segregation of global, sensorimotor, and association systems using resting-state functional MRI data, we analyzed how segregation relates to cognitive performance in both classical and eye movement tasks across age strata and whether this is influenced by the degree of neuropathology. Our analyses included 6,455 participants (30-95 years) of the community-based Rhineland Study. System segregation indices were based on functional connectivity within and between 12 brain systems. We assessed cognitive performance with tests for memory, processing speed, executive function, and crystallized intelligence and oculomotor tasks. Multivariable regression models confirmed that brain systems become less segregated with age (e.g., global segregation: standardized regression coefficient (ß) = -0.298; 95
KW  - aging (Other)
KW  - brain systems segregation (Other)
KW  - cognition (Other)
KW  - neuroaxonal damage (Other)
KW  - resting-state fMRI (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40937157
C2  - pmc:PMC12421694
DO  - DOI:10.1162/IMAG.a.138
UR  - https://pub.dzne.de/record/281361
ER  -