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000281363 1001_ $$aHetzer, Martin W$$b0
000281363 245__ $$aLong-lived cellular molecules in the brain.
000281363 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2025
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000281363 520__ $$aIn long-lived mammals, including humans, brain cell homeostasis is critical for maintaining brain function throughout life. Most neurons are generated during development and must maintain their cellular identity and plasticity to preserve brain function. Although extensive studies indicate the importance of recycling and regenerating cellular molecules to maintain cellular homeostasis, recent evidence has shown that some proteins and RNAs do not turn over for months and even years. We propose that these long-lived cellular molecules may be the basis for maintaining brain function in the long term, but also a potential convergent target of brain aging. We highlight key discoveries and challenges, and propose potential directions to unravel the mystery of brain cell longevity.
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000281363 650_7 $$2Other$$abrain aging
000281363 650_7 $$2Other$$aepigenetic regulation
000281363 650_7 $$2Other$$along-lived RNA
000281363 650_7 $$2Other$$along-lived proteins
000281363 650_7 $$2Other$$along-term memory
000281363 650_7 $$2Other$$alongevity
000281363 650_2 $$2MeSH$$aHumans
000281363 650_2 $$2MeSH$$aAnimals
000281363 650_2 $$2MeSH$$aBrain: cytology
000281363 650_2 $$2MeSH$$aBrain: metabolism
000281363 650_2 $$2MeSH$$aBrain: physiology
000281363 650_2 $$2MeSH$$aNeurons: physiology
000281363 650_2 $$2MeSH$$aNeurons: metabolism
000281363 650_2 $$2MeSH$$aHomeostasis: physiology
000281363 650_2 $$2MeSH$$aAging: physiology
000281363 7001_ $$0P:(DE-2719)2814117$$aToda, Tomohisa$$b1$$eLast author$$udzne
000281363 773__ $$0PERI:(DE-600)2011000-5$$a10.1016/j.tins.2025.07.004$$gVol. 48, no. 9, p. 645 - 654$$n9$$p645 - 654$$tTrends in neurosciences$$v48$$x0378-5912$$y2025
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