TY  - JOUR
AU  - Hetzer, Martin W
AU  - Toda, Tomohisa
TI  - Long-lived cellular molecules in the brain.
JO  - Trends in neurosciences
VL  - 48
IS  - 9
SN  - 0378-5912
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2025-01110
SP  - 645 - 654
PY  - 2025
AB  - In long-lived mammals, including humans, brain cell homeostasis is critical for maintaining brain function throughout life. Most neurons are generated during development and must maintain their cellular identity and plasticity to preserve brain function. Although extensive studies indicate the importance of recycling and regenerating cellular molecules to maintain cellular homeostasis, recent evidence has shown that some proteins and RNAs do not turn over for months and even years. We propose that these long-lived cellular molecules may be the basis for maintaining brain function in the long term, but also a potential convergent target of brain aging. We highlight key discoveries and challenges, and propose potential directions to unravel the mystery of brain cell longevity.
KW  - Humans
KW  - Animals
KW  - Brain: cytology
KW  - Brain: metabolism
KW  - Brain: physiology
KW  - Neurons: physiology
KW  - Neurons: metabolism
KW  - Homeostasis: physiology
KW  - Aging: physiology
KW  - brain aging (Other)
KW  - epigenetic regulation (Other)
KW  - long-lived RNA (Other)
KW  - long-lived proteins (Other)
KW  - long-term memory (Other)
KW  - longevity (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40744775
DO  - DOI:10.1016/j.tins.2025.07.004
UR  - https://pub.dzne.de/record/281363
ER  -