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@ARTICLE{Hetzer:281363,
      author       = {Hetzer, Martin W and Toda, Tomohisa},
      title        = {{L}ong-lived cellular molecules in the brain.},
      journal      = {Trends in neurosciences},
      volume       = {48},
      number       = {9},
      issn         = {0378-5912},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2025-01110},
      pages        = {645 - 654},
      year         = {2025},
      abstract     = {In long-lived mammals, including humans, brain cell
                      homeostasis is critical for maintaining brain function
                      throughout life. Most neurons are generated during
                      development and must maintain their cellular identity and
                      plasticity to preserve brain function. Although extensive
                      studies indicate the importance of recycling and
                      regenerating cellular molecules to maintain cellular
                      homeostasis, recent evidence has shown that some proteins
                      and RNAs do not turn over for months and even years. We
                      propose that these long-lived cellular molecules may be the
                      basis for maintaining brain function in the long term, but
                      also a potential convergent target of brain aging. We
                      highlight key discoveries and challenges, and propose
                      potential directions to unravel the mystery of brain cell
                      longevity.},
      subtyp        = {Review Article},
      keywords     = {Humans / Animals / Brain: cytology / Brain: metabolism /
                      Brain: physiology / Neurons: physiology / Neurons:
                      metabolism / Homeostasis: physiology / Aging: physiology /
                      brain aging (Other) / epigenetic regulation (Other) /
                      long-lived RNA (Other) / long-lived proteins (Other) /
                      long-term memory (Other) / longevity (Other)},
      cin          = {AG Toda},
      ddc          = {610},
      cid          = {I:(DE-2719)1710014},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40744775},
      doi          = {10.1016/j.tins.2025.07.004},
      url          = {https://pub.dzne.de/record/281363},
}